Tuning the allosteric sequestration of anticancer drugs for developing cooperative nano-antidotes
A dual-cavity basket 16-, holding six γ-aminobutyric acids at its termini, encapsulates variously sized aromatics 2-7+, including four anthracyclines (8+-11+), driven by the hydrophobic effect and hydrogen bonding (HB). In particular, the formation of stable (K = 1012 M-2) anthracycline complexes [(8+-11+)2⊂16-], assembled into nanoparticles, occurred with positive homotropic cooperativity (α = 4K2/K1 = 1.1 ± 0.3 × 102-1.3 ± 0.7 × 103) in PBS medium. Importantly, weakening the first binding event (K1, i.e. by removing HBs) turned the second one (K2) more favorable. The finding is of interest for developing cooperative nano-antidotes acting as biodetoxifying agents.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:56 |
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| Enthalten in: |
Chemical communications (Cambridge, England) - 56(2020), 8 vom: 25. Jan., Seite 1271-1274 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Wang, Weikun [VerfasserIn] |
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| Links: |
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| Themen: |
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| Anmerkungen: |
Date Completed 14.02.2020 Date Revised 14.02.2020 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1039/c9cc09373g |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM305030051 |
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| 520 | |a A dual-cavity basket 16-, holding six γ-aminobutyric acids at its termini, encapsulates variously sized aromatics 2-7+, including four anthracyclines (8+-11+), driven by the hydrophobic effect and hydrogen bonding (HB). In particular, the formation of stable (K = 1012 M-2) anthracycline complexes [(8+-11+)2⊂16-], assembled into nanoparticles, occurred with positive homotropic cooperativity (α = 4K2/K1 = 1.1 ± 0.3 × 102-1.3 ± 0.7 × 103) in PBS medium. Importantly, weakening the first binding event (K1, i.e. by removing HBs) turned the second one (K2) more favorable. The finding is of interest for developing cooperative nano-antidotes acting as biodetoxifying agents | ||
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Anthracyclines |2 NLM | |
| 650 | 7 | |a Antidotes |2 NLM | |
| 650 | 7 | |a Antineoplastic Agents |2 NLM | |
| 700 | 1 | |a Finnegan, Tyler J |e verfasserin |4 aut | |
| 700 | 1 | |a Lei, Zhiquan |e verfasserin |4 aut | |
| 700 | 1 | |a Zhu, Xingrong |e verfasserin |4 aut | |
| 700 | 1 | |a Moore, Curtis E |e verfasserin |4 aut | |
| 700 | 1 | |a Shi, Kejia |e verfasserin |4 aut | |
| 700 | 1 | |a Badjić, Jovica D |e verfasserin |4 aut | |
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