Prognostic value of 18F-FDG PET/CT parameters and histopathologic variables in head and neck cancer

Copyright © 2019 Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. Published by Elsevier Editora Ltda. All rights reserved..

INTRODUCTION: 18F-fluorodeoxyglucose positron emission tomography/computed tomography parameters such as; maximum standardized uptake values, standard metabolic tumor volume and otal lesion glycosis are important prognostic biomarkers in cancers.

OBJECTIVE: To investigate the prognostic value of these parameters in patients with head and neck cancers.

METHODS: We performed a retrospective study including 47 patients with head and neck cancer who underwent18F-fluorodeoxyglucose positron emission tomography/computed tomography prior to treatment. Standard metabolic tumor volume, otal lesion glycosis and standardized uptake were measured for each patient. The prognostic value of quantitative 18F-fluorodeoxyglucose positron emission tomography/computed tomography parameters and clinicopathologic variables on disease free survival and overall survival were analyzed.

RESULTS: The median (range) standard metabolic tumor volume and otal lesion glycosis and standardized uptake were 7.63cm3 (0.6-34.3), 68.9g (2.58-524.5g), 13.89 (4.89-33.03g/mL), respectively. Lymph node metastases and tumour differentiation were significant variables for disease free survival and overall survival, however, all 18F-fluorodeoxyglucose positron emission tomography/computed tomography parameters were not associated with disease- free survival and overall survival.

CONCLUSION: Pretreatment quantities positron emission tomography parameters did not predict survival in head and neck cancer.

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:87

Enthalten in:

Brazilian journal of otorhinolaryngology - 87(2021), 4 vom: 15. Juli, Seite 452-456

Sprache:

Englisch

Beteiligte Personen:

Aslan, Hale [VerfasserIn]
Cekin, Gul [VerfasserIn]
Pinar, Ercan [VerfasserIn]
Yazir, Mustafa [VerfasserIn]
Imre, Abdulkadir [VerfasserIn]
Songu, Murat [VerfasserIn]
Islek, Akif [VerfasserIn]
Aladag, Ibrahim [VerfasserIn]
Oncel, Ismail Semih [VerfasserIn]

Links:

Volltext

Themen:

0Z5B2CJX4D
Fluorodeoxyglucose F18
Head and neck cancer (18)F-FDG PET/CT
Journal Article
Metabolic parameters
Prognosis

Anmerkungen:

Date Completed 20.07.2021

Date Revised 02.09.2022

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1016/j.bjorl.2019.10.014

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM304987328