Remote Control of Mechanical Forces via Mitochondrial-Targeted Magnetic Nanospinners for Efficient Cancer Treatment
© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim..
In cells, mechanical forces play a key role in impacting cell behaviors, including adhesion, differentiation, migration, and death. Herein, a 20 nm mitochondria-targeted zinc-doped iron oxide nanocube is designed as a nanospinner to exert mechanical forces under a rotating magnetic field (RMF) at 15 Hz and 40 mT to fight against cancer. The nanospinners can efficiently target the mitochondria of cancer cells. By means of the RMF, the nanocubes assemble in alignment with the external field and produce a localized mechanical force to impair the cancer cells. Both in vitro and in vivo studies show that the nanospinners can damage the cancer cells and reduce the brain tumor growth rate after the application of the RMF. This nanoplatform provides an effective magnetomechanical approach to treat deep-seated tumors in a spatiotemporal fashion.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2020 |
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Erschienen: |
2020 |
Enthalten in: |
Zur Gesamtaufnahme - volume:16 |
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Enthalten in: |
Small (Weinheim an der Bergstrasse, Germany) - 16(2020), 3 vom: 06. Jan., Seite e1905424 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Chen, Mengwei [VerfasserIn] |
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Links: |
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Themen: |
Apoptosis |
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Anmerkungen: |
Date Completed 08.02.2021 Date Revised 08.02.2021 published: Print-Electronic Citation Status MEDLINE |
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doi: |
10.1002/smll.201905424 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM304683345 |
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520 | |a © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. | ||
520 | |a In cells, mechanical forces play a key role in impacting cell behaviors, including adhesion, differentiation, migration, and death. Herein, a 20 nm mitochondria-targeted zinc-doped iron oxide nanocube is designed as a nanospinner to exert mechanical forces under a rotating magnetic field (RMF) at 15 Hz and 40 mT to fight against cancer. The nanospinners can efficiently target the mitochondria of cancer cells. By means of the RMF, the nanocubes assemble in alignment with the external field and produce a localized mechanical force to impair the cancer cells. Both in vitro and in vivo studies show that the nanospinners can damage the cancer cells and reduce the brain tumor growth rate after the application of the RMF. This nanoplatform provides an effective magnetomechanical approach to treat deep-seated tumors in a spatiotemporal fashion | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Research Support, N.I.H., Extramural | |
650 | 4 | |a Research Support, Non-U.S. Gov't | |
650 | 4 | |a apoptosis | |
650 | 4 | |a cancer | |
650 | 4 | |a magnetic nanocubes | |
650 | 4 | |a magnetomechanical destruction | |
650 | 4 | |a mitochondrial | |
700 | 1 | |a Wu, Jiaojiao |e verfasserin |4 aut | |
700 | 1 | |a Ning, Peng |e verfasserin |4 aut | |
700 | 1 | |a Wang, Jingjing |e verfasserin |4 aut | |
700 | 1 | |a Ma, Zuan |e verfasserin |4 aut | |
700 | 1 | |a Huang, Liqun |e verfasserin |4 aut | |
700 | 1 | |a Plaza, Gustavo R |e verfasserin |4 aut | |
700 | 1 | |a Shen, Yajing |e verfasserin |4 aut | |
700 | 1 | |a Xu, Chang |e verfasserin |4 aut | |
700 | 1 | |a Han, Yu |e verfasserin |4 aut | |
700 | 1 | |a Lesniak, Maciej S |e verfasserin |4 aut | |
700 | 1 | |a Liu, Zhongmin |e verfasserin |4 aut | |
700 | 1 | |a Cheng, Yu |e verfasserin |4 aut | |
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