Remote Control of Mechanical Forces via Mitochondrial-Targeted Magnetic Nanospinners for Efficient Cancer Treatment

© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim..

In cells, mechanical forces play a key role in impacting cell behaviors, including adhesion, differentiation, migration, and death. Herein, a 20 nm mitochondria-targeted zinc-doped iron oxide nanocube is designed as a nanospinner to exert mechanical forces under a rotating magnetic field (RMF) at 15 Hz and 40 mT to fight against cancer. The nanospinners can efficiently target the mitochondria of cancer cells. By means of the RMF, the nanocubes assemble in alignment with the external field and produce a localized mechanical force to impair the cancer cells. Both in vitro and in vivo studies show that the nanospinners can damage the cancer cells and reduce the brain tumor growth rate after the application of the RMF. This nanoplatform provides an effective magnetomechanical approach to treat deep-seated tumors in a spatiotemporal fashion.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:16

Enthalten in:

Small (Weinheim an der Bergstrasse, Germany) - 16(2020), 3 vom: 06. Jan., Seite e1905424

Sprache:

Englisch

Beteiligte Personen:

Chen, Mengwei [VerfasserIn]
Wu, Jiaojiao [VerfasserIn]
Ning, Peng [VerfasserIn]
Wang, Jingjing [VerfasserIn]
Ma, Zuan [VerfasserIn]
Huang, Liqun [VerfasserIn]
Plaza, Gustavo R [VerfasserIn]
Shen, Yajing [VerfasserIn]
Xu, Chang [VerfasserIn]
Han, Yu [VerfasserIn]
Lesniak, Maciej S [VerfasserIn]
Liu, Zhongmin [VerfasserIn]
Cheng, Yu [VerfasserIn]

Links:

Volltext

Themen:

Apoptosis
Cancer
Journal Article
Magnetic nanocubes
Magnetomechanical destruction
Mitochondrial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Anmerkungen:

Date Completed 08.02.2021

Date Revised 08.02.2021

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1002/smll.201905424

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM304683345