Prediction Characteristics of Oral Absorption Simulation Software Evaluated Using Structurally Diverse Low-Solubility Drugs
Copyright © 2020 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved..
The purpose of the present study was to characterize current biopharmaceutics modeling and simulation software regarding the prediction of the fraction of a dose absorbed (Fa) in humans. As commercial software products, GastroPlus™ and Simcyp® were used. In addition, the gastrointestinal unified theoretical framework, a simple and publicly accessible model, was used as a benchmark. The Fa prediction characteristics for a total of 96 clinical Fa data of 27 model drugs were systematically evaluated using the default settings of each software product. The molecular weight, dissociation constant, octanol-water partition coefficient, solubility in biorelevant media, dose, and particle size of model drugs were used as input data. Although the same input parameters were used, GastroPlus™, Simcyp®, and the gastrointestinal unified theoretical framework showed different Fa prediction characteristics depending on the rate-limiting steps of oral drug absorption. The results of the present study would be of great help for the overall progression of physiologically based absorption models.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:109 |
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| Enthalten in: |
Journal of pharmaceutical sciences - 109(2020), 3 vom: 15. März, Seite 1403-1416 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Matsumura, Naoya [VerfasserIn] |
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| Links: |
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| Themen: |
Dissolution |
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| Anmerkungen: |
Date Completed 17.06.2021 Date Revised 17.06.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.xphs.2019.12.009 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM304642061 |
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| 520 | |a Copyright © 2020 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a The purpose of the present study was to characterize current biopharmaceutics modeling and simulation software regarding the prediction of the fraction of a dose absorbed (Fa) in humans. As commercial software products, GastroPlus™ and Simcyp® were used. In addition, the gastrointestinal unified theoretical framework, a simple and publicly accessible model, was used as a benchmark. The Fa prediction characteristics for a total of 96 clinical Fa data of 27 model drugs were systematically evaluated using the default settings of each software product. The molecular weight, dissociation constant, octanol-water partition coefficient, solubility in biorelevant media, dose, and particle size of model drugs were used as input data. Although the same input parameters were used, GastroPlus™, Simcyp®, and the gastrointestinal unified theoretical framework showed different Fa prediction characteristics depending on the rate-limiting steps of oral drug absorption. The results of the present study would be of great help for the overall progression of physiologically based absorption models | ||
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| 700 | 1 | |a Hayashi, Shun |e verfasserin |4 aut | |
| 700 | 1 | |a Akiyama, Yoshiyuki |e verfasserin |4 aut | |
| 700 | 1 | |a Ono, Asami |e verfasserin |4 aut | |
| 700 | 1 | |a Funaki, Satoko |e verfasserin |4 aut | |
| 700 | 1 | |a Tamura, Naomi |e verfasserin |4 aut | |
| 700 | 1 | |a Kimoto, Takahiro |e verfasserin |4 aut | |
| 700 | 1 | |a Jiko, Maiko |e verfasserin |4 aut | |
| 700 | 1 | |a Haruna, Yuka |e verfasserin |4 aut | |
| 700 | 1 | |a Sarashina, Akiko |e verfasserin |4 aut | |
| 700 | 1 | |a Ishida, Masahiro |e verfasserin |4 aut | |
| 700 | 1 | |a Nishiyama, Kotaro |e verfasserin |4 aut | |
| 700 | 1 | |a Fushimi, Masahiro |e verfasserin |4 aut | |
| 700 | 1 | |a Kojima, Yukiko |e verfasserin |4 aut | |
| 700 | 1 | |a Yoneda, Kazuhiro |e verfasserin |4 aut | |
| 700 | 1 | |a Nakanishi, Misato |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Soonih |e verfasserin |4 aut | |
| 700 | 1 | |a Fujita, Takuya |e verfasserin |4 aut | |
| 700 | 1 | |a Sugano, Kiyohiko |e verfasserin |4 aut | |
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