A Case-Control Study on the p73 G4A Gene Polymorphism and Susceptibility to Breast Cancer in an Iranian Population
Copyright© Iranian Public Health Association & Tehran University of Medical Sciences..
BACKGROUND: The tumor protein p73 (TP73) is a homolog of TP53 family. Ectopic p73 overexpression largely mimics p53 activities as a tumor suppressor and activates the transcription of p53-responsive genes and as a result induce apoptosis. This study aimed to investigate the association between p73 G4A polymorphism and the risk of breast cancer in a northeastern Iranian population.
METHODS: This case-control study was performed on 105 patients who admitted in educational hospitals of Mashhad University of Medical Sciences, Iran during 2013-2015, with breast cancer as case group and 120 healthy women as the control group. PCR-CTPP method was used to investigate the relationship between the p73 G4A polymorphism and the risk of breast cancer.
RESULTS: There was no significant association between the AA genotype of the p73 G4A polymorphism and breast cancer in case and control groups. Although G allele frequency was higher in the case group, the abundance of this allele between case and control groups was not statistically meaningful and, as a result, not associated with the risk of breast cancer in this study group.
CONCLUSION: There was no association between G4A p73 polymorphism and the risk of breast cancer in a northeastern Iranian population.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:48 |
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| Enthalten in: |
Iranian journal of public health - 48(2019), 10 vom: 20. Okt., Seite 1855-1860 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Tavakkol Afshari, Zeinab [VerfasserIn] |
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| Themen: |
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| Anmerkungen: |
Date Revised 11.04.2022 published: Print Citation Status PubMed-not-MEDLINE |
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| Förderinstitution / Projekttitel: |
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NLM304510696 |
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| 100 | 1 | |a Tavakkol Afshari, Zeinab |e verfasserin |4 aut | |
| 245 | 1 | 2 | |a A Case-Control Study on the p73 G4A Gene Polymorphism and Susceptibility to Breast Cancer in an Iranian Population |
| 264 | 1 | |c 2019 | |
| 336 | |a Text |b txt |2 rdacontent | ||
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| 500 | |a Date Revised 11.04.2022 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a Copyright© Iranian Public Health Association & Tehran University of Medical Sciences. | ||
| 520 | |a BACKGROUND: The tumor protein p73 (TP73) is a homolog of TP53 family. Ectopic p73 overexpression largely mimics p53 activities as a tumor suppressor and activates the transcription of p53-responsive genes and as a result induce apoptosis. This study aimed to investigate the association between p73 G4A polymorphism and the risk of breast cancer in a northeastern Iranian population | ||
| 520 | |a METHODS: This case-control study was performed on 105 patients who admitted in educational hospitals of Mashhad University of Medical Sciences, Iran during 2013-2015, with breast cancer as case group and 120 healthy women as the control group. PCR-CTPP method was used to investigate the relationship between the p73 G4A polymorphism and the risk of breast cancer | ||
| 520 | |a RESULTS: There was no significant association between the AA genotype of the p73 G4A polymorphism and breast cancer in case and control groups. Although G allele frequency was higher in the case group, the abundance of this allele between case and control groups was not statistically meaningful and, as a result, not associated with the risk of breast cancer in this study group | ||
| 520 | |a CONCLUSION: There was no association between G4A p73 polymorphism and the risk of breast cancer in a northeastern Iranian population | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Breast cancer | |
| 650 | 4 | |a Polymorphism | |
| 650 | 4 | |a Tumor protein p73 | |
| 700 | 1 | |a Gholizadeh, Zahra |e verfasserin |4 aut | |
| 700 | 1 | |a Nikpoor, Amin Reza |e verfasserin |4 aut | |
| 700 | 1 | |a Tavakkol Afshari, Jalil |e verfasserin |4 aut | |
| 700 | 1 | |a Ganjali, Rashin |e verfasserin |4 aut | |
| 700 | 1 | |a Homaei Shandiz, Fatemeh |e verfasserin |4 aut | |
| 700 | 1 | |a Jamialahmadi, Khadijeh |e verfasserin |4 aut | |
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