Androgen receptor suppresses prostate cancer metastasis but promotes bladder cancer metastasis via differentially altering miRNA525-5p/SLPI-mediated vasculogenic mimicry formation
Copyright © 2019 Elsevier B.V. All rights reserved..
Early studies suggest that the androgen receptor (AR) may play differential roles in influencing prostate cancer (PCa) and bladder cancer (BCa) metastasis, but the underlying mechanisms remain unclear. Here, we found that the AR might function via differentially altering vasculogenic mimicry (VM) formation to either decrease PCa metastasis or increase BCa metastasis. Mechanism dissection showed that the AR could differentially alter the expression of the VM marker SLPI through miR-525-5p to regulate SLPI; moreover, it could either increase miR-525-5p transcription in PCa or decrease it in BCa via binding to different androgen-response-elements (AREs) located at different positions in the miR-525 precursor promoter. Further, results from liquid chromatography-mass spectrometry (LC-MS) showed that the co-factors of AR in PCa and BCa are NFIX and HDAC2, respectively. Together, these results provide the first detailed mechanism of how the AR can differentially alter PCa and BCa metastasis; thus, targeting the newly identified AR-miR-525-5p-SLPI axis may help suppress metastasis.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2020 |
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Erschienen: |
2020 |
Enthalten in: |
Zur Gesamtaufnahme - volume:473 |
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Enthalten in: |
Cancer letters - 473(2020) vom: 31. März, Seite 118-129 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Yang, Zhao [VerfasserIn] |
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Links: |
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Anmerkungen: |
Date Completed 05.10.2020 Date Revised 04.12.2021 published: Print-Electronic Citation Status MEDLINE |
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doi: |
10.1016/j.canlet.2019.12.018 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM304445258 |
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245 | 1 | 0 | |a Androgen receptor suppresses prostate cancer metastasis but promotes bladder cancer metastasis via differentially altering miRNA525-5p/SLPI-mediated vasculogenic mimicry formation |
264 | 1 | |c 2020 | |
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500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Copyright © 2019 Elsevier B.V. All rights reserved. | ||
520 | |a Early studies suggest that the androgen receptor (AR) may play differential roles in influencing prostate cancer (PCa) and bladder cancer (BCa) metastasis, but the underlying mechanisms remain unclear. Here, we found that the AR might function via differentially altering vasculogenic mimicry (VM) formation to either decrease PCa metastasis or increase BCa metastasis. Mechanism dissection showed that the AR could differentially alter the expression of the VM marker SLPI through miR-525-5p to regulate SLPI; moreover, it could either increase miR-525-5p transcription in PCa or decrease it in BCa via binding to different androgen-response-elements (AREs) located at different positions in the miR-525 precursor promoter. Further, results from liquid chromatography-mass spectrometry (LC-MS) showed that the co-factors of AR in PCa and BCa are NFIX and HDAC2, respectively. Together, these results provide the first detailed mechanism of how the AR can differentially alter PCa and BCa metastasis; thus, targeting the newly identified AR-miR-525-5p-SLPI axis may help suppress metastasis | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Research Support, Non-U.S. Gov't | |
650 | 4 | |a Androgen receptor | |
650 | 4 | |a Bladder cancer | |
650 | 4 | |a Prostate cancer | |
650 | 4 | |a Vasculogenic mimicry | |
650 | 4 | |a miRNA-525-5p | |
650 | 7 | |a AR protein, human |2 NLM | |
650 | 7 | |a Androgen Antagonists |2 NLM | |
650 | 7 | |a Antineoplastic Agents |2 NLM | |
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700 | 1 | |a Xie, Hongjun |e verfasserin |4 aut | |
700 | 1 | |a Liu, Tianjie |e verfasserin |4 aut | |
700 | 1 | |a Chen, Yule |e verfasserin |4 aut | |
700 | 1 | |a Ma, Zhenkun |e verfasserin |4 aut | |
700 | 1 | |a Pei, Xinqi |e verfasserin |4 aut | |
700 | 1 | |a Yang, Wenjie |e verfasserin |4 aut | |
700 | 1 | |a Li, Lei |e verfasserin |4 aut | |
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