Autophagy and the Immune Response

Innate immunity and adaptive immunity play critical roles in maintaining normal physiological functions and the development of diseases. In innate immune responses, heterogeneous autophagy can directly remove intracellular pathogens while activating PRRs, including TLRs and NLRs, to trigger their signal transduction pathways and promote NKT cell activation, cytokine secretion, and phagocytosis. In adaptive immune responses, the autophagy reaction has an important effect on the homeostasis, function, and differentiation of T lymphocytes, the survival, and development of B lymphocytes and the survival of plasma cells. This review highlights the key role that autophagy plays in the innate immune system and the acquired immune system. Further clarifying the mechanism by which autophagy regulates the immune system is essential for elucidating the precise mechanisms of various diseases and for developing new treatment methods.

Medienart:

E-Artikel

Erscheinungsjahr:

2019

Erschienen:

2019

Enthalten in:

Zur Gesamtaufnahme - volume:1206

Enthalten in:

Advances in experimental medicine and biology - 1206(2019) vom: 27., Seite 595-634

Sprache:

Englisch

Beteiligte Personen:

Cui, Bing [VerfasserIn]
Lin, Heng [VerfasserIn]
Yu, Jinmei [VerfasserIn]
Yu, Jiaojiao [VerfasserIn]
Hu, Zhuowei [VerfasserIn]

Links:

Volltext

Themen:

Adaptive immunity
Autophagy
Innate immunity
Journal Article
Review

Anmerkungen:

Date Completed 06.12.2019

Date Revised 13.11.2023

published: Print

Citation Status MEDLINE

doi:

10.1007/978-981-15-0602-4_27

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM303792191