Cumulative Evidence for Association between IL-10 Polymorphisms and Kawasaki Disease Susceptibility : A Systematic Review and Meta-Analysis

BACKGROUND: This meta-analysis was carried out to evaluate the associations between IL-10 polymorphisms and Kawasaki disease (KD) risk.

METHODS: A comprehensive literature search was performed using PubMed, EMBASE, China National Knowledge Infrastructure and SciELO for all relevant studies evaluating IL-10 polymorphism and susceptibility to KD. The associations were measured by odds ratios (ORs) and its corresponding 95% confidence intervals (CIs).

RESULTS: A total of 13 studies including four studies on -1082 A > G, four studies on -819 T > C and five studies on -592 A > C polymorphism were selected. Pooled data revealed that IL-10 -592 A > C polymorphism was significantly associated with an increased risk of KD (C vs. A: OR = 0.402, 95% CI 0.194-0.832, p = 0.014). However, IL-10 -1082 A > G and -819 T > C polymorphisms were not significantly associated with risk of KD under all five genetic models.

CONCLUSIONS: Our results revealed that IL-10 -592 A > C polymorphism was associated with risk of KD, while IL-10 -1082 A > G and -819 T > C polymorphisms were not involved in the development of KD.

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:40

Enthalten in:

Fetal and pediatric pathology - 40(2021), 2 vom: 03. Apr., Seite 153-165

Sprache:

Englisch

Beteiligte Personen:

Ferdosian, Farzad [VerfasserIn]
Dastgheib, Seyed Alireza [VerfasserIn]
Morovati-Sharifabad, Majid [VerfasserIn]
Lookzadeh, Mohammad Hosein [VerfasserIn]
Noorishadkam, Mahmood [VerfasserIn]
Mirjalili, Seyed Reza [VerfasserIn]
Akbarian-Bafghi, Mohammad Javad [VerfasserIn]
Neamatzadeh, Hossein [VerfasserIn]

Links:

Volltext

Themen:

130068-27-8
Association
Interleukin 10
Interleukin-10
Journal Article
Kawasaki disease
Meta-Analysis
Meta-analysis
Polymorphism
Systematic Review

Anmerkungen:

Date Completed 27.04.2021

Date Revised 31.05.2022

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1080/15513815.2019.1686789

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM303417595