Cumulative Evidence for Association between IL-10 Polymorphisms and Kawasaki Disease Susceptibility : A Systematic Review and Meta-Analysis
BACKGROUND: This meta-analysis was carried out to evaluate the associations between IL-10 polymorphisms and Kawasaki disease (KD) risk.
METHODS: A comprehensive literature search was performed using PubMed, EMBASE, China National Knowledge Infrastructure and SciELO for all relevant studies evaluating IL-10 polymorphism and susceptibility to KD. The associations were measured by odds ratios (ORs) and its corresponding 95% confidence intervals (CIs).
RESULTS: A total of 13 studies including four studies on -1082 A > G, four studies on -819 T > C and five studies on -592 A > C polymorphism were selected. Pooled data revealed that IL-10 -592 A > C polymorphism was significantly associated with an increased risk of KD (C vs. A: OR = 0.402, 95% CI 0.194-0.832, p = 0.014). However, IL-10 -1082 A > G and -819 T > C polymorphisms were not significantly associated with risk of KD under all five genetic models.
CONCLUSIONS: Our results revealed that IL-10 -592 A > C polymorphism was associated with risk of KD, while IL-10 -1082 A > G and -819 T > C polymorphisms were not involved in the development of KD.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2021 |
---|---|
Erschienen: |
2021 |
Enthalten in: |
Zur Gesamtaufnahme - volume:40 |
---|---|
Enthalten in: |
Fetal and pediatric pathology - 40(2021), 2 vom: 03. Apr., Seite 153-165 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Ferdosian, Farzad [VerfasserIn] |
---|
Links: |
---|
Themen: |
130068-27-8 |
---|
Anmerkungen: |
Date Completed 27.04.2021 Date Revised 31.05.2022 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.1080/15513815.2019.1686789 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM303417595 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM303417595 | ||
003 | DE-627 | ||
005 | 20231225112801.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231225s2021 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1080/15513815.2019.1686789 |2 doi | |
028 | 5 | 2 | |a pubmed24n1011.xml |
035 | |a (DE-627)NLM303417595 | ||
035 | |a (NLM)31738634 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Ferdosian, Farzad |e verfasserin |4 aut | |
245 | 1 | 0 | |a Cumulative Evidence for Association between IL-10 Polymorphisms and Kawasaki Disease Susceptibility |b A Systematic Review and Meta-Analysis |
264 | 1 | |c 2021 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 27.04.2021 | ||
500 | |a Date Revised 31.05.2022 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a BACKGROUND: This meta-analysis was carried out to evaluate the associations between IL-10 polymorphisms and Kawasaki disease (KD) risk | ||
520 | |a METHODS: A comprehensive literature search was performed using PubMed, EMBASE, China National Knowledge Infrastructure and SciELO for all relevant studies evaluating IL-10 polymorphism and susceptibility to KD. The associations were measured by odds ratios (ORs) and its corresponding 95% confidence intervals (CIs) | ||
520 | |a RESULTS: A total of 13 studies including four studies on -1082 A > G, four studies on -819 T > C and five studies on -592 A > C polymorphism were selected. Pooled data revealed that IL-10 -592 A > C polymorphism was significantly associated with an increased risk of KD (C vs. A: OR = 0.402, 95% CI 0.194-0.832, p = 0.014). However, IL-10 -1082 A > G and -819 T > C polymorphisms were not significantly associated with risk of KD under all five genetic models | ||
520 | |a CONCLUSIONS: Our results revealed that IL-10 -592 A > C polymorphism was associated with risk of KD, while IL-10 -1082 A > G and -819 T > C polymorphisms were not involved in the development of KD | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Meta-Analysis | |
650 | 4 | |a Systematic Review | |
650 | 4 | |a Kawasaki disease | |
650 | 4 | |a association | |
650 | 4 | |a interleukin 10 | |
650 | 4 | |a meta-analysis | |
650 | 4 | |a polymorphism | |
650 | 7 | |a Interleukin-10 |2 NLM | |
650 | 7 | |a 130068-27-8 |2 NLM | |
700 | 1 | |a Dastgheib, Seyed Alireza |e verfasserin |4 aut | |
700 | 1 | |a Morovati-Sharifabad, Majid |e verfasserin |4 aut | |
700 | 1 | |a Lookzadeh, Mohammad Hosein |e verfasserin |4 aut | |
700 | 1 | |a Noorishadkam, Mahmood |e verfasserin |4 aut | |
700 | 1 | |a Mirjalili, Seyed Reza |e verfasserin |4 aut | |
700 | 1 | |a Akbarian-Bafghi, Mohammad Javad |e verfasserin |4 aut | |
700 | 1 | |a Neamatzadeh, Hossein |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Fetal and pediatric pathology |d 2004 |g 40(2021), 2 vom: 03. Apr., Seite 153-165 |w (DE-627)NLM150461623 |x 1551-3823 |7 nnns |
773 | 1 | 8 | |g volume:40 |g year:2021 |g number:2 |g day:03 |g month:04 |g pages:153-165 |
856 | 4 | 0 | |u http://dx.doi.org/10.1080/15513815.2019.1686789 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 40 |j 2021 |e 2 |b 03 |c 04 |h 153-165 |