Altered putamen and cerebellum connectivity among different subtypes of Parkinson's disease

© 2019 The Authors. CNS Neuroscience & Therapeutics Published by John Wiley & Sons Ltd..

OBJECTIVE: Impairment of basal ganglia (BG)-thalamo-cortical circuit causes various symptoms of Parkinson's disease (PD). We investigated the functional connectivity (FC) patterns of putamen among PD subtypes and healthy control (HC) and explored their clinical significance.

METHODS: A total of 16 patients with tremor-dominant (TD) PD, 23 patients with postural instability and gait difficulty-dominant (PIGD) PD, and 31 HC that underwent functional magnetic resonance imaging were observed. Voxel-wise FC analysis was performed by computing correlation between bilateral putamen and other voxels within the brain. Correlation analysis was performed between FC strength and clinical symptoms.

RESULTS: Compared with PIGD group, TD group showed increased FC between left putamen and right cerebellum lobule VI and cerebellum crus I, then we compared the cerebellum FC difference among the three groups. The cerebellum lobule VI FC difference was mainly involved in motor related cortex, and the cerebellum crus I FC difference was related to cognition areas. While compared with HC, TD and PIGD groups both had significant FC difference brain areas correlated with motor and cognition symptoms. The connectively of putamen and right cerebellum lobules VI and I showed positive correlation with tremor and Montreal Cognitive Assessment degree of scores, respectively. The connectivity of putamen and sensorimotor cortex had negative correlation with PIGD scores.

CONCLUSIONS: The altered connectivity of BG-cortical circuit in patients with PD was related to PIGD symptoms. Motor and cognitive impairments declined slower in patients with TD PD, which may be related to increased functional connectivity between putamen and cerebellum.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:26

Enthalten in:

CNS neuroscience & therapeutics - 26(2020), 2 vom: 02. Feb., Seite 207-214

Sprache:

Englisch

Beteiligte Personen:

Shen, Bo [VerfasserIn]
Pan, Yang [VerfasserIn]
Jiang, Xu [VerfasserIn]
Wu, Zhuang [VerfasserIn]
Zhu, Jun [VerfasserIn]
Dong, Jingde [VerfasserIn]
Zhang, Wenbin [VerfasserIn]
Xu, Pingyi [VerfasserIn]
Dai, Yakang [VerfasserIn]
Gao, Yang [VerfasserIn]
Xiao, Chaoyong [VerfasserIn]
Zhang, Li [VerfasserIn]

Links:

Volltext

Themen:

Cerebellar
Functional connectivity
Journal Article
Parkinson's disease
Putamen
Research Support, Non-U.S. Gov't
Tremor

Anmerkungen:

Date Completed 22.06.2021

Date Revised 22.06.2021

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1111/cns.13259

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM303334851