Anti-inflammatory effect of lanoconazole on 12-O-tetradecanoylphorbol-13-acetate- and 2,4,6-trinitrophenyl chloride-induced skin inflammation in mice

© 2019 Blackwell Verlag GmbH..

BACKGROUND: Lanoconazole (LCZ) is a topical antifungal agent clinically used to treat fungal infections such as tinea pedis. LCZ has not only antifungal effects but also anti-inflammatory effects, which have the potential to provide additional clinical benefits. However, the characteristic features of the inhibitory effects of LCZ on skin inflammation remain unclear.

OBJECTIVE: We evaluated the inhibitory effects of topical application of LCZ, and compared the effects of LCZ with those of other antifungal agents including liranaftate, terbinafine and amorolfine.

METHODS: Each antifungal agent was topically applied on 12-O-tetradecanoylphorbol-13-acetate-induced irritant dermatitis and 2,4,6-trinitrophenyl chloride-induced contact dermatitis in mice (BALB/c). The ear thickness, myeloperoxidase activity and inflammatory mediator contents were evaluated.

RESULTS: LCZ dose-dependently suppressed 12-O-tetradecanoylphorbol-13-acetate-induced irritant dermatitis, suppressed the production of neutrophil chemotactic factors such as keratinocyte-derived chemokine and macrophage inflammatory protein-2, and inhibited neutrophil infiltration to the inflammation site. Moreover, 1% LCZ reduced the ear swelling in mice with 2,4,6-trinitrophenyl chloride-induced contact dermatitis in accordance with the inhibition of interferon-γ production. The inhibitory potency of LCZ on these types of dermatitis in mice was stronger than that of other types of antifungal agents.

CONCLUSION: The anti-inflammatory effects of LCZ were exerted through the inhibition of inflammatory mediator production. These effects may contribute to the relief of dermatitis symptoms in patients with tinea pedis.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:63

Enthalten in:

Mycoses - 63(2020), 2 vom: 09. Feb., Seite 189-196

Sprache:

Englisch

Beteiligte Personen:

Nakamura, Aki [VerfasserIn]
Uratsuji, Hideya [VerfasserIn]
Yamada, Yoshihito [VerfasserIn]
Hashimoto, Kei [VerfasserIn]
Nozawa, Naoki [VerfasserIn]
Matsumoto, Tatsumi [VerfasserIn]

Links:

Volltext

Themen:

4E7858311F
A49OS0F91S
Anti-Inflammatory Agents, Non-Steroidal
Anti-inflammatory agents
Antifungal Agents
Antifungal agents
CXC
Chemokines
Dermatitis:contact
Dermatitis:irritant
Dermatomycoses
Imidazoles
Journal Article
Lanoconazole
Latoconazole
NI40JAQ945
Pharmacology
Picrates
Picric acid
Tetradecanoylphorbol Acetate

Anmerkungen:

Date Completed 31.08.2020

Date Revised 10.01.2021

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1111/myc.13034

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM303276479