Is rectus abdominis thickness associated with survival among patients with liver cirrhosis? A prospective cohort study

BACKGROUND: Sarcopenia may affect patients with liver cirrhosis and worsen disease outcomes.

OBJECTIVES: To evaluate ultrasound-measured psoas major (PM) and rectus abdominis (RA) thickness for predicting survival among patients with liver cirrhosis.

DESIGN AND SETTING: Prospective cohort study in a tertiary-level hospital.

METHODS: 61 patients with liver cirrhosis were prospectively included during a 15-month period and followed up for at least six months. Cirrhosis was classified using the Child-Pugh score. Sarcopenia was assessed using surrogate parameters: handgrip strength (HGS), mid-arm muscle circumference (MAMC) and SGA (subjective global assessment). We used ultrasound to measure RA and PM thickness at admission.

RESULTS: There were 41 men. The patients' mean age was 58.03 ± 10.8 years. 26.22% of them were Child-Pugh A, 45.9% B and 27.86% C. The patients were followed up for 11.9 ± 5.63 months. RA thickness correlated moderately with MAMC (r = 0. 596; P < 0.0001) and HGS (r = 0.515; P < 0.0001) and decreased with increasing SGA class (A, 10.6 ± 2.8 mm; B, 8.3 ± 1.9 mm; C, 6.5 ± 1.9 mm; P < 0.0001). Survival at six months was independently predicted by using the model for end-stage liver disease-serum sodium score (odds ratio, OR 1.305; 95% OR confidence interval 1.083-1.572; P = 0.005). Survival during follow-up was independently predicted by RA thickness (hazard ratio, HR 0.701; 95% HR confidence interval 0.533-0.922; P = 0.011) and ascites (HR 1.876; 95% HR confidence interval 1.078-3.267; P = 0.026). PM thickness did not have any predictive value.

CONCLUSIONS: As a surrogate marker of sarcopenia, RA thickness may predict survival among patients with liver cirrhosis.

Medienart:

E-Artikel

Erscheinungsjahr:

2019

Erschienen:

2019

Enthalten in:

Zur Gesamtaufnahme - volume:137

Enthalten in:

Sao Paulo medical journal = Revista paulista de medicina - 137(2019), 5 vom: 11. Sept., Seite 401-406

Sprache:

Englisch

Beteiligte Personen:

Ciocîrlan, Maria [VerfasserIn]
Mănuc, Mircea [VerfasserIn]
Diculescu, Mircea [VerfasserIn]
Ciocîrlan, Mihai [VerfasserIn]

Links:

Volltext

Themen:

Journal Article

Anmerkungen:

Date Completed 10.03.2020

Date Revised 14.12.2022

published: Print

Citation Status MEDLINE

doi:

10.1590/1516-3180.2019.000406082019

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM303254084