Dual Analysis of Loss to Follow-up for Perinatally HIV-Infected Adolescents Receiving Combination Antiretroviral Therapy in Asia
BACKGROUND: Perinatally HIV-infected adolescents (PHIVA) are an expanding population vulnerable to loss to follow-up (LTFU). Understanding the epidemiology and factors for LTFU is complicated by varying LTFU definitions.
SETTING: Asian regional cohort incorporating 16 pediatric HIV services across 6 countries.
METHODS: Data from PHIVA (aged 10-19 years) who received combination antiretroviral therapy 2007-2016 were used to analyze LTFU through (1) an International epidemiology Databases to Evaluate AIDS (IeDEA) method that determined LTFU as >90 days late for an estimated next scheduled appointment without returning to care and (2) the absence of patient-level data for >365 days before the last data transfer from clinic sites. Descriptive analyses and competing-risk survival and regression analyses were used to evaluate LTFU epidemiology and associated factors when analyzed using each method.
RESULTS: Of 3509 included PHIVA, 275 (7.8%) met IeDEA and 149 (4.3%) met 365-day absence LTFU criteria. Cumulative incidence of LTFU was 19.9% and 11.8% using IeDEA and 365-day absence criteria, respectively. Risk factors for LTFU across both criteria included the following: age at combination antiretroviral therapy initiation <5 years compared with age ≥5 years, rural clinic settings compared with urban clinic settings, and high viral loads compared with undetectable viral loads. Age 10-14 years compared with age 15-19 years was another risk factor identified using 365-day absence criteria but not IeDEA LTFU criteria.
CONCLUSIONS: Between 12% and 20% of PHIVA were determined LTFU with treatment fatigue and rural treatment settings consistent risk factors. Better tracking of adolescents is required to provide a definitive understanding of LTFU and optimize evidence-based models of care.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:82 |
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| Enthalten in: |
Journal of acquired immune deficiency syndromes (1999) - 82(2019), 5 vom: 15. Dez., Seite 431-438 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Bartlett, Adam W [VerfasserIn] |
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| Links: |
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| Themen: |
Anti-Retroviral Agents |
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| Anmerkungen: |
Date Completed 02.06.2020 Date Revised 15.12.2020 published: Print Citation Status MEDLINE |
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| doi: |
10.1097/QAI.0000000000002184 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM30318079X |
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| 100 | 1 | |a Bartlett, Adam W |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Dual Analysis of Loss to Follow-up for Perinatally HIV-Infected Adolescents Receiving Combination Antiretroviral Therapy in Asia |
| 264 | 1 | |c 2019 | |
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| 500 | |a Date Completed 02.06.2020 | ||
| 500 | |a Date Revised 15.12.2020 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: Perinatally HIV-infected adolescents (PHIVA) are an expanding population vulnerable to loss to follow-up (LTFU). Understanding the epidemiology and factors for LTFU is complicated by varying LTFU definitions | ||
| 520 | |a SETTING: Asian regional cohort incorporating 16 pediatric HIV services across 6 countries | ||
| 520 | |a METHODS: Data from PHIVA (aged 10-19 years) who received combination antiretroviral therapy 2007-2016 were used to analyze LTFU through (1) an International epidemiology Databases to Evaluate AIDS (IeDEA) method that determined LTFU as >90 days late for an estimated next scheduled appointment without returning to care and (2) the absence of patient-level data for >365 days before the last data transfer from clinic sites. Descriptive analyses and competing-risk survival and regression analyses were used to evaluate LTFU epidemiology and associated factors when analyzed using each method | ||
| 520 | |a RESULTS: Of 3509 included PHIVA, 275 (7.8%) met IeDEA and 149 (4.3%) met 365-day absence LTFU criteria. Cumulative incidence of LTFU was 19.9% and 11.8% using IeDEA and 365-day absence criteria, respectively. Risk factors for LTFU across both criteria included the following: age at combination antiretroviral therapy initiation <5 years compared with age ≥5 years, rural clinic settings compared with urban clinic settings, and high viral loads compared with undetectable viral loads. Age 10-14 years compared with age 15-19 years was another risk factor identified using 365-day absence criteria but not IeDEA LTFU criteria | ||
| 520 | |a CONCLUSIONS: Between 12% and 20% of PHIVA were determined LTFU with treatment fatigue and rural treatment settings consistent risk factors. Better tracking of adolescents is required to provide a definitive understanding of LTFU and optimize evidence-based models of care | ||
| 650 | 4 | |a Comparative Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a Anti-Retroviral Agents |2 NLM | |
| 700 | 1 | |a Lumbiganon, Pagakrong |e verfasserin |4 aut | |
| 700 | 1 | |a Jamal Mohamed, Thahira A |e verfasserin |4 aut | |
| 700 | 1 | |a Lapphra, Keswadee |e verfasserin |4 aut | |
| 700 | 1 | |a Muktiarti, Dina |e verfasserin |4 aut | |
| 700 | 1 | |a Du, Quy Tuan |e verfasserin |4 aut | |
| 700 | 1 | |a Hansudewechakul, Rawiwan |e verfasserin |4 aut | |
| 700 | 1 | |a Ly, Penh Sun |e verfasserin |4 aut | |
| 700 | 1 | |a Truong, Khanh Huu |e verfasserin |4 aut | |
| 700 | 1 | |a Van Nguyen, Lam |e verfasserin |4 aut | |
| 700 | 1 | |a Puthanakit, Thanyawee |e verfasserin |4 aut | |
| 700 | 1 | |a Sudjaritruk, Tavitiya |e verfasserin |4 aut | |
| 700 | 1 | |a Chokephaibulkit, Kulkanya |e verfasserin |4 aut | |
| 700 | 1 | |a Do, Viet Chau |e verfasserin |4 aut | |
| 700 | 1 | |a Kumarasamy, Nagalingeswaran |e verfasserin |4 aut | |
| 700 | 1 | |a Nik Yusoff, Nik Khairulddin |e verfasserin |4 aut | |
| 700 | 1 | |a Kurniati, Nia |e verfasserin |4 aut | |
| 700 | 1 | |a Fong, Moy Siew |e verfasserin |4 aut | |
| 700 | 1 | |a Wati, Dewi Kumara |e verfasserin |4 aut | |
| 700 | 1 | |a Nallusamy, Revathy |e verfasserin |4 aut | |
| 700 | 1 | |a Sohn, Annette H |e verfasserin |4 aut | |
| 700 | 1 | |a Kariminia, Azar |e verfasserin |4 aut | |
| 700 | 0 | |a TREAT Asia Pediatric HIV Observational Database of IeDEA Asia-Pacific |e verfasserin |4 aut | |
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