Auditory sensory gating in young adolescents with early-onset psychosis : a comparison with attention deficit/hyperactivity disorder

Numerous studies have demonstrated impaired sensory gating in schizophrenia and this impairment has been proposed as a candidate biomarker for the disorder. The typical age of onset for schizophrenia is early adulthood, however a sizable group of patients present with psychotic symptoms before the age of 18, commonly referred to as early-onset psychosis (EOP). How an earlier onset influences sensory gating is currently unknown. Impaired sensory gating may not be specific to psychosis, but rather a shared disturbance of neurodevelopmental disorders, such as attention deficit/hyperactivity disorder (ADHD). Therefore, the current study investigated P50 suppression in young adolescents (12-17 years old) with either EOP (N = 55) or ADHD (N = 28) and age and gender matched healthy controls (HC) (N = 71). In addition to P50 suppression, N100 and P200 suppression data were also analyzed. No significant group differences in either raw mean P50 amplitude or mean P50 gating ratios were observed between EOP, ADHD, and HC. Additionally, we observed no P50 suppression deficit in those EOP patients diagnosed with schizophrenia (N = 39). Similarly, we observed no differences in N100 or P200 between the three groups. Healthy levels of P50 suppression were found in both patient groups. The results are in line with some previous studies showing healthy levels of P50 suppression in the early phases of schizophrenia. Our findings do not support P50 sensory gating as a valid biomarker for EOP or ADHD.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:45

Enthalten in:

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 45(2020), 4 vom: 24. März, Seite 649-655

Sprache:

Englisch

Beteiligte Personen:

Lemvigh, Cecilie Koldbæk [VerfasserIn]
Jepsen, Jens Richardt Møllegaard [VerfasserIn]
Fagerlund, Birgitte [VerfasserIn]
Pagsberg, Anne Katrine [VerfasserIn]
Glenthøj, Birte Yding [VerfasserIn]
Rydkjær, Jacob [VerfasserIn]
Oranje, Bob [VerfasserIn]

Links:

Volltext

Themen:

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Anmerkungen:

Date Completed 28.12.2020

Date Revised 02.03.2021

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1038/s41386-019-0555-9

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM302542027