Co-Operation between Aneuploidy and Metabolic Changes in Driving Tumorigenesis
Alterations from the normal set of chromosomes are extremely common as cells progress toward tumourigenesis. Similarly, we expect to see disruption of normal cellular metabolism, particularly in the use of glucose. In this review, we discuss the connections between these two processes: how chromosomal aberrations lead to metabolic disruption, and vice versa. Both processes typically result in the production of elevated levels of reactive oxygen species, so we particularly focus on their role in mediating oncogenic changes.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:20 |
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| Enthalten in: |
International journal of molecular sciences - 20(2019), 18 vom: 18. Sept. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Newman, David L [VerfasserIn] |
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| Links: |
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| Themen: |
Aneuploidy |
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| Anmerkungen: |
Date Completed 07.02.2020 Date Revised 07.02.2020 published: Electronic Citation Status MEDLINE |
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| doi: |
10.3390/ijms20184611 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM301483612 |
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| 520 | |a Alterations from the normal set of chromosomes are extremely common as cells progress toward tumourigenesis. Similarly, we expect to see disruption of normal cellular metabolism, particularly in the use of glucose. In this review, we discuss the connections between these two processes: how chromosomal aberrations lead to metabolic disruption, and vice versa. Both processes typically result in the production of elevated levels of reactive oxygen species, so we particularly focus on their role in mediating oncogenic changes | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a aneuploidy | |
| 650 | 4 | |a glycolysis | |
| 650 | 4 | |a metabolism | |
| 650 | 4 | |a oxidative stress | |
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