Intestinal microbiota - A modulator of the Trypanosoma cruzi-vector-host triad
Copyright © 2019 Elsevier Ltd. All rights reserved..
Chagas disease affects millions of people, and it is a major cause of death in Latin America. Prevention and development of an effective treatment for this infection can be favored by a more thorough understanding of T. cruzi interaction with the microbiome of vectors and hosts. Next-generation sequencing technology vastly broadened the knowledge about intestinal bacteria composition, showing that microbiota within each host (triatomines and mammals) is composed by high diversity of species, although few dominant phyla. This fact may represent an ecological balance that was acquired during the evolutionary process of the microbiome-host complex, and that serves to perpetuate this system. In this context, commensal microbiota is also essential to protect hosts, conferring them resistance to pathogens colonization. However, in some situations, the microbiota is not able to prevent infection but only modulate it. Here we will review the role of the microbiota on the parasite-vector-host triad with a focus on the kinetoplastida of medical importance Trypanosoma cruzi. Novel strategies to control Chagas disease based on intestinal microbiome will also be discussed.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:137 |
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| Enthalten in: |
Microbial pathogenesis - 137(2019) vom: 15. Dez., Seite 103711 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Teotônio, Isabella Márcia Soares Nogueira [VerfasserIn] |
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| Links: |
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| Themen: |
Chagas disease |
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| Anmerkungen: |
Date Completed 30.03.2020 Date Revised 30.03.2020 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.micpath.2019.103711 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM301004927 |
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| 520 | |a Copyright © 2019 Elsevier Ltd. All rights reserved. | ||
| 520 | |a Chagas disease affects millions of people, and it is a major cause of death in Latin America. Prevention and development of an effective treatment for this infection can be favored by a more thorough understanding of T. cruzi interaction with the microbiome of vectors and hosts. Next-generation sequencing technology vastly broadened the knowledge about intestinal bacteria composition, showing that microbiota within each host (triatomines and mammals) is composed by high diversity of species, although few dominant phyla. This fact may represent an ecological balance that was acquired during the evolutionary process of the microbiome-host complex, and that serves to perpetuate this system. In this context, commensal microbiota is also essential to protect hosts, conferring them resistance to pathogens colonization. However, in some situations, the microbiota is not able to prevent infection but only modulate it. Here we will review the role of the microbiota on the parasite-vector-host triad with a focus on the kinetoplastida of medical importance Trypanosoma cruzi. Novel strategies to control Chagas disease based on intestinal microbiome will also be discussed | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Chagas disease | |
| 650 | 4 | |a Host | |
| 650 | 4 | |a Intestinal microbiota | |
| 650 | 4 | |a Trypanosoma cruzi | |
| 650 | 4 | |a Vector | |
| 700 | 1 | |a Dias, Nayra |e verfasserin |4 aut | |
| 700 | 1 | |a Hagström-Bex, Luciana |e verfasserin |4 aut | |
| 700 | 1 | |a Nitz, Nadjar |e verfasserin |4 aut | |
| 700 | 1 | |a Francisco, Amanda Fortes |e verfasserin |4 aut | |
| 700 | 1 | |a Hecht, Mariana |e verfasserin |4 aut | |
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