Low-dose statin pretreatment reduces stroke severity and improves functional outcomes

OBJECTIVES: Pre-stroke statin use reduces stroke severity and improves functional outcomes; however, whether low-dose statins as a primary preventive measure have similar effects on the Chinese population remains unclear.

METHODS: Consecutive cases of ischaemic stroke between May 2011 and January 2017 were retrospectively analysed. The primary endpoints were stroke severity on admission and functional outcomes at 90 days. The secondary endpoints were factors related to lower stroke severity on admission. Propensity score matching and logistic regression analyses were performed.

RESULTS: Of the 1878 patients, 6.4% and 23.8% were pre-stroke statin users before and after propensity matching, respectively, reducing the National Institutes of Health Stroke Scale (NIHSS) score on admission from 5 (2-9) to 3 (2-4) (P < 0.001). Patients receiving pretreatment with low-dose statins tended to have a better mRS distribution (median mRS score 2 [1-3] vs. 3 [2-4], P = 0.007) and a higher likelihood of favourable functional outcomes (FFOs) at 90 days (61 [65.6%] vs. 151 [50.8%], P = 0.005). The logistic regression analysis showed that low-dose statins taken before stroke (odds ratio [OR] = 0.15, 95% confidence interval [CI] = 0.08-0.27, P < 0.001) and being male (OR = 0.81, 95% CI = 0.66-0.99, P = 0.035) were related to a lower stroke severity on admission but not among patients with atrial fibrillation (OR = 1.65, 95% CI = 1.12-2.44, P = 0.012) or elevated white blood cell (WBC) counts (OR = 1.12, 95% CI = 1.08-1.17, P < 0.001).

CONCLUSIONS: Pretreatment with low-dose statins reduced initial stroke severity, improved functional outcomes at 90 days and was independently associated with a lower stroke severity on admission among Chinese patients.

Medienart:

E-Artikel

Erscheinungsjahr:

2019

Erschienen:

2019

Enthalten in:

Zur Gesamtaufnahme - volume:266

Enthalten in:

Journal of neurology - 266(2019), 12 vom: 03. Dez., Seite 2970-2978

Sprache:

Englisch

Beteiligte Personen:

Dong, Shuju [VerfasserIn]
Guo, Jian [VerfasserIn]
Fang, Jinghuan [VerfasserIn]
Hong, Ye [VerfasserIn]
Cui, Shuhui [VerfasserIn]
He, Li [VerfasserIn]

Links:

Volltext

Themen:

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Journal Article
Low-dose statins
Outcome
Severity
Stroke

Anmerkungen:

Date Completed 14.04.2020

Date Revised 10.01.2021

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1007/s00415-019-09520-9

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM300775083