Down syndrome with primary thyroid diffuse large B-cell lymphoma and Hashimoto thyroiditis : A CARE compliant case report
RATIONALE: Adult patients with Down syndrome (DS) commonly develop Hashimoto thyroiditis (HT). However, primary diffuse large B-cell lymphoma (DLBCL) of the thyroid is uncommon, and its simultaneous occurrence with HT is very rare. To our knowledge, coexisting DLBCL and HT in a patient with DS has not been reported in the medical literature.
PATIENT CONCERNS: We present a 43-year-old woman with DS who reported progressive swelling of the neck on the right side and dyspnea over the previous 1 month, with associated neck ache, hoarseness, and dysphagia. Thyroid ultrasonography and computed tomography of the neck revealed a large mass in the right lobe compressing the surrounding tissues.
DIAGNOSES: Based on the clinical and histopathologic findings, the patient was diagnosed with coexisting primary thyroid DLBCL and HT.
INTERVENTIONS: A palliative unilateral thyroidectomy was performed; postoperative histopathology and immunohistochemistry revealed thyroid DLBCL and HT. The patient was scheduled for chemotherapy and targeted therapy after recovering from surgery.
OUTCOMES: The patient died 3 weeks after surgery due to asphyxia caused by uncontrollable growth of recurrent tumor.
LESSONS: The coexistence of DS, primary thyroid DLBCL, and HT is very rare. There is no standardized approach to the clinical identification of primary thyroid lymphoma (PTL), making early diagnosis difficult. A multidisciplinary approach and close follow-up are needed. The mechanisms of the link between DS and PTL are poorly understood and remain to be elucidated.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:98 |
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| Enthalten in: |
Medicine - 98(2019), 35 vom: 01. Aug., Seite e16994 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Wei, Luyang [VerfasserIn] |
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| Links: |
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| Themen: |
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| Anmerkungen: |
Date Completed 16.09.2019 Date Revised 05.10.2022 published: Print Citation Status MEDLINE |
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| doi: |
10.1097/MD.0000000000016994 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM300743858 |
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| 100 | 1 | |a Wei, Luyang |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Down syndrome with primary thyroid diffuse large B-cell lymphoma and Hashimoto thyroiditis |b A CARE compliant case report |
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| 500 | |a Date Completed 16.09.2019 | ||
| 500 | |a Date Revised 05.10.2022 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a RATIONALE: Adult patients with Down syndrome (DS) commonly develop Hashimoto thyroiditis (HT). However, primary diffuse large B-cell lymphoma (DLBCL) of the thyroid is uncommon, and its simultaneous occurrence with HT is very rare. To our knowledge, coexisting DLBCL and HT in a patient with DS has not been reported in the medical literature | ||
| 520 | |a PATIENT CONCERNS: We present a 43-year-old woman with DS who reported progressive swelling of the neck on the right side and dyspnea over the previous 1 month, with associated neck ache, hoarseness, and dysphagia. Thyroid ultrasonography and computed tomography of the neck revealed a large mass in the right lobe compressing the surrounding tissues | ||
| 520 | |a DIAGNOSES: Based on the clinical and histopathologic findings, the patient was diagnosed with coexisting primary thyroid DLBCL and HT | ||
| 520 | |a INTERVENTIONS: A palliative unilateral thyroidectomy was performed; postoperative histopathology and immunohistochemistry revealed thyroid DLBCL and HT. The patient was scheduled for chemotherapy and targeted therapy after recovering from surgery | ||
| 520 | |a OUTCOMES: The patient died 3 weeks after surgery due to asphyxia caused by uncontrollable growth of recurrent tumor | ||
| 520 | |a LESSONS: The coexistence of DS, primary thyroid DLBCL, and HT is very rare. There is no standardized approach to the clinical identification of primary thyroid lymphoma (PTL), making early diagnosis difficult. A multidisciplinary approach and close follow-up are needed. The mechanisms of the link between DS and PTL are poorly understood and remain to be elucidated | ||
| 650 | 4 | |a Case Reports | |
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| 700 | 1 | |a Li, Yalun |e verfasserin |4 aut | |
| 700 | 1 | |a Zheng, Xiaodan |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Huaxin |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Zhongtao |e verfasserin |4 aut | |
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