Magnetic resonance imaging (MRI) reveals high cardiac ejection fractions in red-footed tortoises (Chelonoidis carbonarius)
© 2019. Published by The Company of Biologists Ltd..
The ejection fraction of the trabeculated cardiac ventricle of reptiles has not previously been measured. Here, we used the gold standard clinical methodology - electrocardiogram-gated flow magnetic resonance imaging (MRI) - to validate stroke volume measurements and end diastolic ventricular blood volume. This produced an estimate of ejection fraction in our study species, the red footed tortoise Chelonoidis carbonarius (n=5), under isoflurane anaesthesia of 88±11%. After reduction of the prevailing right-to-left intraventricular shunt through the action of atropine, the ejection fraction was 96±6%. This methodology opens new avenues for studying the complex hearts of ectotherms, and validating hypotheses on the function of a more highly trabeculated heart than that of endotherms, which have lower ejection fractions.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:222 |
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| Enthalten in: |
The Journal of experimental biology - 222(2019), Pt 18 vom: 16. Sept. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Williams, Catherine J A [VerfasserIn] |
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| Links: |
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| Themen: |
7C0697DR9I |
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| Anmerkungen: |
Date Completed 05.08.2020 Date Revised 05.08.2020 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1242/jeb.206714 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM300494297 |
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| 100 | 1 | |a Williams, Catherine J A |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Magnetic resonance imaging (MRI) reveals high cardiac ejection fractions in red-footed tortoises (Chelonoidis carbonarius) |
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| 500 | |a Date Revised 05.08.2020 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2019. Published by The Company of Biologists Ltd. | ||
| 520 | |a The ejection fraction of the trabeculated cardiac ventricle of reptiles has not previously been measured. Here, we used the gold standard clinical methodology - electrocardiogram-gated flow magnetic resonance imaging (MRI) - to validate stroke volume measurements and end diastolic ventricular blood volume. This produced an estimate of ejection fraction in our study species, the red footed tortoise Chelonoidis carbonarius (n=5), under isoflurane anaesthesia of 88±11%. After reduction of the prevailing right-to-left intraventricular shunt through the action of atropine, the ejection fraction was 96±6%. This methodology opens new avenues for studying the complex hearts of ectotherms, and validating hypotheses on the function of a more highly trabeculated heart than that of endotherms, which have lower ejection fractions | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Ejection fraction | |
| 650 | 4 | |a MRI | |
| 650 | 4 | |a Reptile | |
| 650 | 4 | |a Stroke volume | |
| 650 | 4 | |a Trabeculation | |
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| 700 | 1 | |a Greunz, Eva M |e verfasserin |4 aut | |
| 700 | 1 | |a Ringgaard, Steffen |e verfasserin |4 aut | |
| 700 | 1 | |a Hansen, Kasper |e verfasserin |4 aut | |
| 700 | 1 | |a Bertelsen, Mads F |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Tobias |e verfasserin |4 aut | |
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