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Targeting pteridine reductase 1 and dihydrofolate reductase : the old is a new trend for leishmaniasis drug discovery

Leishmaniasis is one of the major neglected tropical diseases in the world and it is considered endemic in 88 countries. This disease is transmitted by a Leishmania spp. infected sandfly and it may lead to cutaneous or systemic manifestations. The preconized treatment has low efficacy and there are cases of resistance to some drugs. Therefore, the search for new efficient molecular targets that can lead to the preparation of new drugs must be pursued. This review aims to evaluate both Leishmania enzymes PTR1 and DHFR-TS as potential drug targets, highlight their inhibitors and to discuss critically the use of chemoinformatics to elucidate interactions and propose new molecules against these enzymes

Year of Publication: 2019
Contained in: Future medicinal chemistry Vol. 11, No. 16 (2019), p. 2107-2130
All journal articles: Search for all articles in this journal
Language: English
Contributors: das Neves, Gustavo Machado | Author
Kagami, Luciano P
Gonçalves, Itamar L
Eifler-Lima, Vera L
Full text access:
Electronic availability is being checked...
Links: Full Text (dx.doi.org)
Keywords: Journal Article
dihydrofolate reductase
folate metabolism
leishmaniasis
medicinal chemistry
molecular modeling
pteridine reductase 1
ISSN: 1756-8927
Note: Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Notes: Date Revised 20.09.2019
published: Print-Electronic
Citation Status In-Data-Review
Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Physical Description: Online-Ressource
ID (e.g. DOI, URN): 10.4155/fmc-2018-0512
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