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Inactivation of oral biofilms using visible light and water-filtered infrared A radiation and indocyanine green

Aim: To investigate the antimicrobial photodynamic therapy (aPDT) of visible light and water-filtered infrared A radiation in combination with indocyanine green (ICG) on planktonic oral microorganisms as well as on oral biofilm. Methods: The irradiation was conducted for 5 min in combination with ICG. Treatment with chlorhexidine served as a positive control. The number of colony forming units and bacterial vitality were quantified. Results: All tested bacterial strains and salivary bacteria were killed at a level of 3log10. The colony forming units of the initial mature oral biofilms were strongly reduced. The high bactericidal effect of aPDT was confirmed by live/dead staining. Conclusion: The aPDT using visible light and water-filtered infrared A radiation and ICG has the potential to treat periodontitis and peri-implantitis

Year of Publication: 2019
Contained in: Future medicinal chemistry Vol. 11, No. 14 (2019), p. 1721-1739
All journal articles: Search for all articles in this journal
Language: English
Contributors: Burchard, Thomas | Author
Karygianni, Lamprini
Hellwig, Elmar
Follo, Marie
Wrbas, Thomas
Wittmer, Annette
Vach, Kirstin
Al-Ahmad, Ali
Full text access:
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Links: Full Text (dx.doi.org)
Keywords: ICG
Journal Article
VIS+wIRA
aPDT
antimicrobial photodynamic therapy
indocyanine green
oral biofilm
visible light and water-filtered infrared A
ISSN: 1756-8927
Note: Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Notes: Date Revised 10.09.2019
published: Print-Electronic
Citation Status In-Data-Review
Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Physical Description: Online-Ressource
ID (e.g. DOI, URN): 10.4155/fmc-2018-0522
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