Clinical efficacy of herbal extracts in treatment of mild to moderate acne vulgaris : an 8-week, double-blinded, randomized, controlled trial
BACKGROUND: Herbal extracts with fewer adverse effects can be an alternative to these drugs because they can target various molecular pathways of acne pathogenesis.
OBJECTIVES: To evaluate the clinical efficacy of herbal extracts (mangosteen, Lithospermum officinale, Tribulus terrestris L., Houttuynia cordata Thunb) for the treatment of mild to moderate acne vulgaris.
METHODS: Sixty patients were randomized in a 1:1 ratio to receive blinded treatment with herbal extracts or vehicle for 8 weeks. Inflammatory and non-inflammatory acne lesion counts, Investigator's Global Assessment, patient's satisfaction and safety profiles were assessed. We also performed skin biopsy at baseline and week 8 to confirm immunological changes with immunohistochemistry staining.
RESULTS: By the end of the study period, both inflammatory and non-inflammatory acne lesion counts were significantly decreased in herbal extracts group (p< .05). In immunohistochemistry staining, expressions of IL-1α, IL-8, and keratin 16 were significantly decreased in herbal extracts group compared to vehicle group from baseline to week 8. There was no serious adverse events in both groups.
CONCLUSIONS: This herbal extracts can be a new therapeutic option for patients with mild to moderate acne vulgaris who are reluctant to use drugs.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:32 |
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| Enthalten in: |
The Journal of dermatological treatment - 32(2021), 3 vom: 21. Mai, Seite 297-301 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Yang, Ji Hoon [VerfasserIn] |
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| Links: |
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| Themen: |
Acne |
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| Anmerkungen: |
Date Completed 21.06.2021 Date Revised 22.04.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1080/09546634.2019.1657792 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM300349912 |
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| 100 | 1 | |a Yang, Ji Hoon |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Clinical efficacy of herbal extracts in treatment of mild to moderate acne vulgaris |b an 8-week, double-blinded, randomized, controlled trial |
| 264 | 1 | |c 2021 | |
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| 500 | |a Date Completed 21.06.2021 | ||
| 500 | |a Date Revised 22.04.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: Herbal extracts with fewer adverse effects can be an alternative to these drugs because they can target various molecular pathways of acne pathogenesis | ||
| 520 | |a OBJECTIVES: To evaluate the clinical efficacy of herbal extracts (mangosteen, Lithospermum officinale, Tribulus terrestris L., Houttuynia cordata Thunb) for the treatment of mild to moderate acne vulgaris | ||
| 520 | |a METHODS: Sixty patients were randomized in a 1:1 ratio to receive blinded treatment with herbal extracts or vehicle for 8 weeks. Inflammatory and non-inflammatory acne lesion counts, Investigator's Global Assessment, patient's satisfaction and safety profiles were assessed. We also performed skin biopsy at baseline and week 8 to confirm immunological changes with immunohistochemistry staining | ||
| 520 | |a RESULTS: By the end of the study period, both inflammatory and non-inflammatory acne lesion counts were significantly decreased in herbal extracts group (p< .05). In immunohistochemistry staining, expressions of IL-1α, IL-8, and keratin 16 were significantly decreased in herbal extracts group compared to vehicle group from baseline to week 8. There was no serious adverse events in both groups | ||
| 520 | |a CONCLUSIONS: This herbal extracts can be a new therapeutic option for patients with mild to moderate acne vulgaris who are reluctant to use drugs | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Randomized Controlled Trial | |
| 650 | 4 | |a Acne | |
| 650 | 4 | |a herbal extracts | |
| 650 | 4 | |a inflammation | |
| 650 | 7 | |a Interleukin-1alpha |2 NLM | |
| 650 | 7 | |a Plant Extracts |2 NLM | |
| 700 | 1 | |a Hwang, Eun Ju |e verfasserin |4 aut | |
| 700 | 1 | |a Moon, Jungyoon |e verfasserin |4 aut | |
| 700 | 1 | |a Yoon, Ji Young |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Ji Won |e verfasserin |4 aut | |
| 700 | 1 | |a Choi, Sungjun |e verfasserin |4 aut | |
| 700 | 1 | |a Cho, Soo Ick |e verfasserin |4 aut | |
| 700 | 1 | |a Suh, Dae Hun |e verfasserin |4 aut | |
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