Association between H19 polymorphisms and NSCLC risk in a Chinese Population
PURPOSE: Long non-coding RNAs (lncRNA) polymorphisms have been reported to associate with the carcinogenicity mechanisms. The association between lncRNA H19 polymorphisms and the risk of non-small cell lung cancer (NSCLC) in Chinese population has not been reported yet. We designed this case-control study to evaluate the effects of H19 polymorphisms on NSCLC susceptibility.
METHODS: In this case-control study, four single nucleotide polymorphisms (SNPs) (rs2067051, rs217727, rs2839698 and rs4929984) in H19 gene were genotyped in a Chinese population which consisted of 564 NSCLC cases and 1536 controls.
RESULTS: rs2067051 was associated with a significantly decreased risk of NSCLC in our population [AA vs. GG: adjusted odds ratio (OR) = 0.75, 95% confidence interval (CI)=0.60-0.93; Additive model: OR=0.79, 95%CI=0.67-0.93)]. rs217727 was related to significantly increased NSCLC susceptibility (TT vs. CC: OR=1.16, 95%CI=1.01-1.33; Additive model: OR=1.16, 95%CI=1.01-1.33). However, no significant association was observed between rs2839698, rs4929984 and NSCLC risk.
CONCLUSIONS: H19 polymorphism rs2067051 and rs217727 might influence NSCLC susceptibility and the mechanism warrants further exploration.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:24 |
|---|---|
| Enthalten in: |
Journal of B.U.ON. : official journal of the Balkan Union of Oncology - 24(2019), 3 vom: 15. Mai, Seite 913-917 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Wang, Guangzheng [VerfasserIn] |
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| Themen: |
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| Anmerkungen: |
Date Completed 02.03.2020 Date Revised 07.12.2022 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM300348541 |
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| 041 | |a eng | ||
| 100 | 1 | |a Wang, Guangzheng |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Association between H19 polymorphisms and NSCLC risk in a Chinese Population |
| 264 | 1 | |c 2019 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 02.03.2020 | ||
| 500 | |a Date Revised 07.12.2022 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a PURPOSE: Long non-coding RNAs (lncRNA) polymorphisms have been reported to associate with the carcinogenicity mechanisms. The association between lncRNA H19 polymorphisms and the risk of non-small cell lung cancer (NSCLC) in Chinese population has not been reported yet. We designed this case-control study to evaluate the effects of H19 polymorphisms on NSCLC susceptibility | ||
| 520 | |a METHODS: In this case-control study, four single nucleotide polymorphisms (SNPs) (rs2067051, rs217727, rs2839698 and rs4929984) in H19 gene were genotyped in a Chinese population which consisted of 564 NSCLC cases and 1536 controls | ||
| 520 | |a RESULTS: rs2067051 was associated with a significantly decreased risk of NSCLC in our population [AA vs. GG: adjusted odds ratio (OR) = 0.75, 95% confidence interval (CI)=0.60-0.93; Additive model: OR=0.79, 95%CI=0.67-0.93)]. rs217727 was related to significantly increased NSCLC susceptibility (TT vs. CC: OR=1.16, 95%CI=1.01-1.33; Additive model: OR=1.16, 95%CI=1.01-1.33). However, no significant association was observed between rs2839698, rs4929984 and NSCLC risk | ||
| 520 | |a CONCLUSIONS: H19 polymorphism rs2067051 and rs217727 might influence NSCLC susceptibility and the mechanism warrants further exploration | ||
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a H19 long non-coding RNA |2 NLM | |
| 650 | 7 | |a RNA, Long Noncoding |2 NLM | |
| 700 | 1 | |a Liu, Qun |e verfasserin |4 aut | |
| 700 | 1 | |a Cui, Kai |e verfasserin |4 aut | |
| 700 | 1 | |a Ma, Aiping |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Hui |e verfasserin |4 aut | |
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