Mercury induces nuclear estrogen receptors to act as vasoconstrictors promoting endothelial denudation via the PI3K/Akt signaling pathway

Copyright © 2019 Elsevier Inc. All rights reserved..

Cardiovascular diseases (CVD) are more frequent among postmenopausal women due to the decline of estrogen concentration in plasma. However, the role of the vascular modulator effect of estrogen is controversial, since it occurs both in physiological and pathological conditions, increasing or reducing vascular reactivity. As mercury is widely associated with the development of CVD, we investigated putative hazardous effects on the mechanisms that modulate vascular reactivity in aortic rings of female Wistar rats promoted by acute mercury exposure. Mercury increased vascular reactivity and oxidative stress possibly due to NADPH oxidase participation, increased production of cyclooxygenase-2 (COX-2) and thromboxane A2 (TXA2) formation. The metal also induced endothelial denudation in the aorta by reducing the bioavailability of nitric oxide (NO) and enhancing the activity of the PI3K/Akt signaling pathway. Mercury exposure also induced nuclear estrogen receptors (ERα, ERβ) to act as vasoconstrictors. Our findings suggest that mercury might increase the chances of developing cardiovascular diseases in females and should be considered an important environmental risk factor.

Medienart:

E-Artikel

Erscheinungsjahr:

2019

Erschienen:

2019

Enthalten in:

Zur Gesamtaufnahme - volume:381

Enthalten in:

Toxicology and applied pharmacology - 381(2019) vom: 15. Okt., Seite 114710

Sprache:

Englisch

Beteiligte Personen:

Cordeiro, Evellyn Rodrigues [VerfasserIn]
Filetti, Filipe Martinuzo [VerfasserIn]
Simões, Maylla Ronacher [VerfasserIn]
Vassallo, Dalton Valentim [VerfasserIn]

Links:

Volltext

Themen:

11062-77-4
31C4KY9ESH
Aorta
Cyclooxygenase 2
EC 1.14.99.1
EC 2.7.11.1
Endothelial Denudation
Estrogen Receptors
FXS1BY2PGL
Journal Article
Mercury
Nitric Oxide
Proto-Oncogene Proteins c-akt
Ptgs2 protein, rat
Reactive Oxygen Species
Receptors, Estrogen
Research Support, Non-U.S. Gov't
Superoxides
Vascular Reactivity

Anmerkungen:

Date Completed 18.05.2020

Date Revised 18.05.2020

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1016/j.taap.2019.114710

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM300260512