Medium-thickness-dependent proton dosimetry for radiobiological experiments

A calibration method was proposed in the present work to determine the medium-thickness-dependent proton doses absorbed in cellular components (i.e., cellular cytoplasm and nucleus) in radiobiological experiments. Consideration of the dependency on medium thickness was crucial as the linear energy transfer (LET) of protons could rise to a sharp peak (known as the Bragg peak) towards the end of their ranges. Relationships between the calibration coefficient R vs medium-layer thickness were obtained for incident proton energies of 10, 15, 20, 25, 30 and 35 MeV, and for various medium thicknesses up to 5000 μm, where R was defined as the ratio DA/DE, DA was the absorbed proton dose in cellular components, and DE was the absorbed proton dose in a separate radiation detector. In the present work, DA and DE were determined using the MCNPX (Monte Carlo N-Particle eXtended) code version 2.4.0. For lower incident proton energies (i.e., 10, 15 and 20 MeV), formation of Bragg-peak-like features were noticed in their R-vs-medium-layer-thickness relationships, and large R values of >7 and >6 were obtained for cytoplasm and nucleus of cells, respectively, which highlighted the importance of careful consideration of the medium thickness in radiobiological experiments.

Medienart:

E-Artikel

Erscheinungsjahr:

2019

Erschienen:

2019

Enthalten in:

Zur Gesamtaufnahme - volume:9

Enthalten in:

Scientific reports - 9(2019), 1 vom: 09. Aug., Seite 11577

Sprache:

Englisch

Beteiligte Personen:

Shahmohammadi Beni, Mehrdad [VerfasserIn]
Krstic, Dragana [VerfasserIn]
Nikezic, Dragoslav [VerfasserIn]
Yu, Kwan Ngok [VerfasserIn]

Links:

Volltext

Themen:

Journal Article
Protons
Research Support, Non-U.S. Gov't

Anmerkungen:

Date Completed 26.10.2020

Date Revised 10.01.2021

published: Electronic

Citation Status MEDLINE

doi:

10.1038/s41598-019-48100-9

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM300102143