Madurastatin D1 and D2, Oxazoline Containing Siderophores Isolated from an Actinomadura sp
Two new siderophores, madurastatin D1 and D2, together with (-)-madurastatin C1, the enantiomer of a known compound, were isolated from marine-derived Actinomadura sp. The presence of an unusual 4-imidazolidinone ring in madurastatins D1 and D2 inspired us to sequence the Actinomadura sp. genome and to identify the mad biosynthetic gene cluster, knowledge of which enables us to now propose a biosynthetic pathway. Madurastatin D1 and D2 are moderately active in antimicrobial assays with M. luteus.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:21 |
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| Enthalten in: |
Organic letters - 21(2019), 16 vom: 16. Aug., Seite 6275-6279 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Yan, Jia-Xuan [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 31.07.2020 Date Revised 13.11.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1021/acs.orglett.9b02159 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM299919099 |
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| 245 | 1 | 0 | |a Madurastatin D1 and D2, Oxazoline Containing Siderophores Isolated from an Actinomadura sp |
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| 500 | |a Date Revised 13.11.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Two new siderophores, madurastatin D1 and D2, together with (-)-madurastatin C1, the enantiomer of a known compound, were isolated from marine-derived Actinomadura sp. The presence of an unusual 4-imidazolidinone ring in madurastatins D1 and D2 inspired us to sequence the Actinomadura sp. genome and to identify the mad biosynthetic gene cluster, knowledge of which enables us to now propose a biosynthetic pathway. Madurastatin D1 and D2 are moderately active in antimicrobial assays with M. luteus | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Research Support, U.S. Gov't, Non-P.H.S. | |
| 650 | 7 | |a Anti-Bacterial Agents |2 NLM | |
| 650 | 7 | |a Oligopeptides |2 NLM | |
| 650 | 7 | |a Oxazoles |2 NLM | |
| 650 | 7 | |a Piperidones |2 NLM | |
| 650 | 7 | |a Siderophores |2 NLM | |
| 650 | 7 | |a madurastatin C1 |2 NLM | |
| 700 | 1 | |a Chevrette, Marc G |e verfasserin |4 aut | |
| 700 | 1 | |a Braun, Doug R |e verfasserin |4 aut | |
| 700 | 1 | |a Harper, Mary Kay |e verfasserin |4 aut | |
| 700 | 1 | |a Currie, Cameron R |e verfasserin |4 aut | |
| 700 | 1 | |a Bugni, Tim S |e verfasserin |4 aut | |
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