REM sleep behavior disorder predicts functional dependency in early Parkinson's disease
Copyright © 2019 Elsevier Ltd. All rights reserved..
OBJECTIVE: To determine whether non-motor symptoms predict the development of functional dependency in Parkinson's disease (PD).
METHODS: This study using the PPMI data included 405 patients with newly diagnosed PD without functional dependency at baseline visit. We collected baseline demographic and clinical data. Non-motor symptoms were measured using well-validated instruments covering neuropsychiatric, sleep-related, olfactory, and autonomic symptoms. The development of dependency was defined to be present if a Schwab and England (S&E) score of less than 80% at any time point remained during the rest of the follow-up. Cox proportional-hazards regression analyses were performed to identify predictors of dependency. To further validate our findings, additional analysis was performed using an S&E cut-off of 60%.
RESULTS: Over a 5-year follow-up period, 61 patients became functionally dependent. The cumulative incidence of dependency was 17% at the 5-year follow-up. Among the non-motor variables, only the REM sleep behavior disorder (RBD) screening questionnaire (RBDSQ) score was associated with the development of dependency. The bradykinesia subscore also predicted dependency. However, when using a cut-off score of 60% or below, the RBDSQ score but not the bradykinesia subscore increased the risk of dependency. The RBDSQ score was further inserted as a dichotomous variable in the multivariable Cox model. The presence of RBD was a significant predictor of dependency for both S&E cut-off scores.
CONCLUSION: The presence of RBD in early PD patients was associated with an increased risk of functional dependency. This finding supports the notion that RBD portends poor prognosis in PD.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:66 |
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| Enthalten in: |
Parkinsonism & related disorders - 66(2019) vom: 15. Sept., Seite 138-142 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kim, Ryul [VerfasserIn] |
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| Links: |
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| Themen: |
Functional dependency |
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| Anmerkungen: |
Date Completed 04.08.2020 Date Revised 04.08.2020 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.parkreldis.2019.07.025 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM299825647 |
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| 500 | |a Date Revised 04.08.2020 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2019 Elsevier Ltd. All rights reserved. | ||
| 520 | |a OBJECTIVE: To determine whether non-motor symptoms predict the development of functional dependency in Parkinson's disease (PD) | ||
| 520 | |a METHODS: This study using the PPMI data included 405 patients with newly diagnosed PD without functional dependency at baseline visit. We collected baseline demographic and clinical data. Non-motor symptoms were measured using well-validated instruments covering neuropsychiatric, sleep-related, olfactory, and autonomic symptoms. The development of dependency was defined to be present if a Schwab and England (S&E) score of less than 80% at any time point remained during the rest of the follow-up. Cox proportional-hazards regression analyses were performed to identify predictors of dependency. To further validate our findings, additional analysis was performed using an S&E cut-off of 60% | ||
| 520 | |a RESULTS: Over a 5-year follow-up period, 61 patients became functionally dependent. The cumulative incidence of dependency was 17% at the 5-year follow-up. Among the non-motor variables, only the REM sleep behavior disorder (RBD) screening questionnaire (RBDSQ) score was associated with the development of dependency. The bradykinesia subscore also predicted dependency. However, when using a cut-off score of 60% or below, the RBDSQ score but not the bradykinesia subscore increased the risk of dependency. The RBDSQ score was further inserted as a dichotomous variable in the multivariable Cox model. The presence of RBD was a significant predictor of dependency for both S&E cut-off scores | ||
| 520 | |a CONCLUSION: The presence of RBD in early PD patients was associated with an increased risk of functional dependency. This finding supports the notion that RBD portends poor prognosis in PD | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Functional dependency | |
| 650 | 4 | |a Non-motor symptoms | |
| 650 | 4 | |a Parkinson's disease | |
| 650 | 4 | |a Predictors | |
| 650 | 4 | |a REM sleep behavior disorder | |
| 700 | 1 | |a Yoo, Dallah |e verfasserin |4 aut | |
| 700 | 1 | |a Im, Jin Hee |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Han-Joon |e verfasserin |4 aut | |
| 700 | 1 | |a Jeon, Beomseok |e verfasserin |4 aut | |
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