The Myb-MuvB Complex Is Required for YAP-Dependent Transcription of Mitotic Genes
Copyright © 2019 The Author(s). Published by Elsevier Inc. All rights reserved..
YAP and TAZ, downstream effectors of the Hippo pathway, are important regulators of proliferation. Here, we show that the ability of YAP to activate mitotic gene expression is dependent on the Myb-MuvB (MMB) complex, a master regulator of genes expressed in the G2/M phase of the cell cycle. By carrying out genome-wide expression and binding analyses, we found that YAP promotes binding of the MMB subunit B-MYB to the promoters of mitotic target genes. YAP binds to B-MYB and stimulates B-MYB chromatin association through distal enhancer elements that interact with MMB-regulated promoters through chromatin looping. The cooperation between YAP and B-MYB is critical for YAP-mediated entry into mitosis. Furthermore, the expression of genes coactivated by YAP and B-MYB is associated with poor survival of cancer patients. Our findings provide a molecular mechanism by which YAP and MMB regulate mitotic gene expression and suggest a link between two cancer-relevant signaling pathways.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:27 |
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| Enthalten in: |
Cell reports - 27(2019), 12 vom: 18. Juni, Seite 3533-3546.e7 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Pattschull, Grit [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 04.08.2020 Date Revised 04.12.2021 published: Print Citation Status MEDLINE |
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| doi: |
10.1016/j.celrep.2019.05.071 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM298326639 |
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| 520 | |a Copyright © 2019 The Author(s). Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a YAP and TAZ, downstream effectors of the Hippo pathway, are important regulators of proliferation. Here, we show that the ability of YAP to activate mitotic gene expression is dependent on the Myb-MuvB (MMB) complex, a master regulator of genes expressed in the G2/M phase of the cell cycle. By carrying out genome-wide expression and binding analyses, we found that YAP promotes binding of the MMB subunit B-MYB to the promoters of mitotic target genes. YAP binds to B-MYB and stimulates B-MYB chromatin association through distal enhancer elements that interact with MMB-regulated promoters through chromatin looping. The cooperation between YAP and B-MYB is critical for YAP-mediated entry into mitosis. Furthermore, the expression of genes coactivated by YAP and B-MYB is associated with poor survival of cancer patients. Our findings provide a molecular mechanism by which YAP and MMB regulate mitotic gene expression and suggest a link between two cancer-relevant signaling pathways | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
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| 650 | 4 | |a Myb-MuvB | |
| 650 | 4 | |a YAP | |
| 650 | 4 | |a enhancer | |
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| 650 | 7 | |a Cell Cycle Proteins |2 NLM | |
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| 650 | 7 | |a Trans-Activators |2 NLM | |
| 650 | 7 | |a Transcription Factors |2 NLM | |
| 650 | 7 | |a YAP-Signaling Proteins |2 NLM | |
| 650 | 7 | |a YAP1 protein, human |2 NLM | |
| 700 | 1 | |a Walz, Susanne |e verfasserin |4 aut | |
| 700 | 1 | |a Gründl, Marco |e verfasserin |4 aut | |
| 700 | 1 | |a Schwab, Melissa |e verfasserin |4 aut | |
| 700 | 1 | |a Rühl, Eva |e verfasserin |4 aut | |
| 700 | 1 | |a Baluapuri, Apoorva |e verfasserin |4 aut | |
| 700 | 1 | |a Cindric-Vranesic, Anita |e verfasserin |4 aut | |
| 700 | 1 | |a Kneitz, Susanne |e verfasserin |4 aut | |
| 700 | 1 | |a Wolf, Elmar |e verfasserin |4 aut | |
| 700 | 1 | |a Ade, Carsten P |e verfasserin |4 aut | |
| 700 | 1 | |a Rosenwald, Andreas |e verfasserin |4 aut | |
| 700 | 1 | |a von Eyss, Björn |e verfasserin |4 aut | |
| 700 | 1 | |a Gaubatz, Stefan |e verfasserin |4 aut | |
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