Distribution and relative frequency of immunohistochemically detected endocrine cells in the stomach of New Zealand White rabbit (Oryctolagus cuniculus)
BACKGROUND: Gastrointestinal (GI) endocrine cells produce many GI hormones that perform various physiological functions of the digestive system.
AIMS: We aimed to investigate the presence and distribution of immunoreactive (IR) endocrine cells to glucagon, somatostatin, cholecystokinin-8 (CCK-8), serotonin, secretin and histamine in the stomach of adult male New Zealand White rabbit (Oryctolagus cuniculus).
METHODS: For immunohistochemical staining, peroxidase anti-peroxidase (PAP) method was applied to stomach samples.
RESULTS: Glucagon-IR cells of closed- and open type were found throughout all the stomach parts examined. Somatostatin-IR cells of closed- and open type in the cardiac and oxyntic glands were localized to deep portions of foveola gastrica. CCK-8 IR cells that were not observed in the cardia and fundus were mostly localized to the glands and lamina epithelialis in the pyloric part near the duodenum. Oval-shaped open and closed type serotonin-IR cells were mostly dispersed throughout the fundic and pyloric glands. Secretin-IR cells were rare in the pyloric and cardiac region although they were not observed in the fundic glands. Histamine-IR cells were rarely found in the cardia, fundus and pylorus.
CONCLUSION: Our findings show that glucagon, histamine, somatostatin, secretin and serotonin might be produced by all the stomach regions while pyloric region had only CCK-8 IR. These distribution patterns also provide further evidence of species-specific differences, which might be important from the evolutionary aspect of the digestive tract in relation to evolutional niches and nutrient resources.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:20 |
|---|---|
| Enthalten in: |
Iranian journal of veterinary research - 20(2019), 1 vom: 01., Seite 39-45 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Türk, S [VerfasserIn] |
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| Themen: |
Endocrine cells |
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| Anmerkungen: |
Date Revised 11.10.2023 published: Print Citation Status PubMed-not-MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM298085879 |
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| 041 | |a eng | ||
| 100 | 1 | |a Türk, S |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Distribution and relative frequency of immunohistochemically detected endocrine cells in the stomach of New Zealand White rabbit (Oryctolagus cuniculus) |
| 264 | 1 | |c 2019 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a Date Revised 11.10.2023 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a BACKGROUND: Gastrointestinal (GI) endocrine cells produce many GI hormones that perform various physiological functions of the digestive system | ||
| 520 | |a AIMS: We aimed to investigate the presence and distribution of immunoreactive (IR) endocrine cells to glucagon, somatostatin, cholecystokinin-8 (CCK-8), serotonin, secretin and histamine in the stomach of adult male New Zealand White rabbit (Oryctolagus cuniculus) | ||
| 520 | |a METHODS: For immunohistochemical staining, peroxidase anti-peroxidase (PAP) method was applied to stomach samples | ||
| 520 | |a RESULTS: Glucagon-IR cells of closed- and open type were found throughout all the stomach parts examined. Somatostatin-IR cells of closed- and open type in the cardiac and oxyntic glands were localized to deep portions of foveola gastrica. CCK-8 IR cells that were not observed in the cardia and fundus were mostly localized to the glands and lamina epithelialis in the pyloric part near the duodenum. Oval-shaped open and closed type serotonin-IR cells were mostly dispersed throughout the fundic and pyloric glands. Secretin-IR cells were rare in the pyloric and cardiac region although they were not observed in the fundic glands. Histamine-IR cells were rarely found in the cardia, fundus and pylorus | ||
| 520 | |a CONCLUSION: Our findings show that glucagon, histamine, somatostatin, secretin and serotonin might be produced by all the stomach regions while pyloric region had only CCK-8 IR. These distribution patterns also provide further evidence of species-specific differences, which might be important from the evolutionary aspect of the digestive tract in relation to evolutional niches and nutrient resources | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Endocrine cells | |
| 650 | 4 | |a Histamine | |
| 650 | 4 | |a Immunoreactivity | |
| 650 | 4 | |a New Zealand White rabbit | |
| 650 | 4 | |a Serotonin | |
| 700 | 1 | |a Çınar, K |e verfasserin |4 aut | |
| 700 | 1 | |a Öztop, M |e verfasserin |4 aut | |
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