Extracorporeal Membrane Oxygenation for Septic Shock

OBJECTIVES: Septic shock carries a high mortality risk. Studies have indicated that patients with septic shock may benefit from extracorporeal membrane oxygenation. In most studies, patients exhibited shock due to myocardial dysfunction rather than distributive/vasoplegic shock. One proposed theory is that venoarterial extracorporeal membrane oxygenation alleviates a failing myocardial function.

DESIGN: Retrospective observational study.

SETTING: Single-center, high-volume extracorporeal membrane oxygenation unit.

PATIENTS: All patients treated for septic shock between 2012 and 2017 with an age greater than 18 years old, fulfilling septic shock criteria according to "Sepsis-3" at acceptance for extracorporeal membrane oxygenation, presence of cardiocirculatory failure requiring a support equivalent to a Vasoactive Inotropic Score greater than 50 to reach a mean arterial pressure greater than 65 mm Hg despite adequate fluid resuscitation, were included.

INTERVENTIONS: None.

MEASUREMENTS AND MAIN RESULTS: Thirty-seven patients, mean age 54.7 years old, were included. Median Simplified Acute Physiology Score-3 score was 86 and Sequential Organ Failure Assessment 16. Twenty-seven patients were submitted to venoarterial and 10 patients to venovenous extracorporeal membrane oxygenation. Hospital survival was 90% for septic shock with left ventricular failure and 64.7% in patients with distributive shock. At long-term follow-up at 46.1 months, total survival was 59.5%. Commencement of venovenous extracorporeal membrane oxygenation and more organ failures at admission showed a less favorable outcome in terms of hospital and long-term survival.

CONCLUSIONS: The current results add not only to the growing evidence of the benefit of venoarterial extracorporeal membrane oxygenation for septic cardiomyopathy but also indicate improved hospital survival in distributive septic shock.

Errataetall:

CommentIn: Crit Care Med. 2019 Dec;47(12):e1039-e1040. - PMID 31738265

Medienart:

E-Artikel

Erscheinungsjahr:

2019

Erschienen:

2019

Enthalten in:

Zur Gesamtaufnahme - volume:47

Enthalten in:

Critical care medicine - 47(2019), 8 vom: 01. Aug., Seite 1097-1105

Sprache:

Englisch

Beteiligte Personen:

Falk, Lars [VerfasserIn]
Hultman, Jan [VerfasserIn]
Broman, Lars Mikael [VerfasserIn]

Links:

Volltext

Themen:

Journal Article

Anmerkungen:

Date Completed 16.04.2020

Date Revised 16.04.2020

published: Print

CommentIn: Crit Care Med. 2019 Dec;47(12):e1039-e1040. - PMID 31738265

Citation Status MEDLINE

doi:

10.1097/CCM.0000000000003819

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM297796712