Cost-Effectiveness Analysis of Non-invasive Prenatal Testing for Down Syndrome in China
OBJECTIVES: There is little evidence in China regarding the cost-effectiveness of non-invasive prenatal testing (NIPT) for Down syndrome (DS). This study aims to evaluate the cost-effectiveness of NIPT and provide evidence to inform decision-making.
METHODS: To determine the cost-effectiveness of NIPT for DS, a decision-analytic model was developed using the TreeAge Pro software from a societal perspective in a simulated cohort of 10 000 pregnant women. Main indicators were based on field surveys from sampled hospitals in four locations in China and a literature review.
RESULTS: The conventional maternal serum screening (CMSS) strategy, contingent screening strategy (NIPT delivered to high risk pregnant women after CMSS), and universal screening strategy could prevent 3.02, 7.53, and 9.97 DS births, respectively. NIPT would decrease unnecessary invasive procedures, resulting in fewer procedure-related miscarriages. The cost-effectiveness ratio of the contingent screening strategy was the lowest. When compared with the CMSS strategy, the incremental cost per DS birth averted by the contingent screening strategy and universal screening strategy were USD 20,160 and 352,388, respectively. One-way sensitivity analysis showed that, if the cost of NIPT could be decreased to USD 76.92, the cost-effectiveness ratio of the universal screening strategy would be lower than the CMSS strategy.
CONCLUSIONS: Although NIPT has the merits of greater effectiveness and safety, CMSS is unlikely to be replaced by NIPT at this time because of NIPT's higher cost. Contingent screening may be an appropriate strategy to balance the effectiveness and cost factors of the new genetic testing technology.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2019 |
---|---|
Erschienen: |
2019 |
Enthalten in: |
Zur Gesamtaufnahme - volume:35 |
---|---|
Enthalten in: |
International journal of technology assessment in health care - 35(2019), 3 vom: 25. Jan., Seite 237-242 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Xu, Yan [VerfasserIn] |
---|
Links: |
---|
Themen: |
Cost-effectiveness analysis |
---|
Anmerkungen: |
Date Completed 29.01.2020 Date Revised 29.01.2020 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.1017/S0266462319000308 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM297498673 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM297498673 | ||
003 | DE-627 | ||
005 | 20231225092125.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231225s2019 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1017/S0266462319000308 |2 doi | |
028 | 5 | 2 | |a pubmed24n0991.xml |
035 | |a (DE-627)NLM297498673 | ||
035 | |a (NLM)31131776 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Xu, Yan |e verfasserin |4 aut | |
245 | 1 | 0 | |a Cost-Effectiveness Analysis of Non-invasive Prenatal Testing for Down Syndrome in China |
264 | 1 | |c 2019 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 29.01.2020 | ||
500 | |a Date Revised 29.01.2020 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a OBJECTIVES: There is little evidence in China regarding the cost-effectiveness of non-invasive prenatal testing (NIPT) for Down syndrome (DS). This study aims to evaluate the cost-effectiveness of NIPT and provide evidence to inform decision-making | ||
520 | |a METHODS: To determine the cost-effectiveness of NIPT for DS, a decision-analytic model was developed using the TreeAge Pro software from a societal perspective in a simulated cohort of 10 000 pregnant women. Main indicators were based on field surveys from sampled hospitals in four locations in China and a literature review | ||
520 | |a RESULTS: The conventional maternal serum screening (CMSS) strategy, contingent screening strategy (NIPT delivered to high risk pregnant women after CMSS), and universal screening strategy could prevent 3.02, 7.53, and 9.97 DS births, respectively. NIPT would decrease unnecessary invasive procedures, resulting in fewer procedure-related miscarriages. The cost-effectiveness ratio of the contingent screening strategy was the lowest. When compared with the CMSS strategy, the incremental cost per DS birth averted by the contingent screening strategy and universal screening strategy were USD 20,160 and 352,388, respectively. One-way sensitivity analysis showed that, if the cost of NIPT could be decreased to USD 76.92, the cost-effectiveness ratio of the universal screening strategy would be lower than the CMSS strategy | ||
520 | |a CONCLUSIONS: Although NIPT has the merits of greater effectiveness and safety, CMSS is unlikely to be replaced by NIPT at this time because of NIPT's higher cost. Contingent screening may be an appropriate strategy to balance the effectiveness and cost factors of the new genetic testing technology | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Down syndrome | |
650 | 4 | |a Non-invasive prenatal testing | |
650 | 4 | |a cost-effectiveness analysis | |
700 | 1 | |a Wei, Yan |e verfasserin |4 aut | |
700 | 1 | |a Ming, Jian |e verfasserin |4 aut | |
700 | 1 | |a Li, Na |e verfasserin |4 aut | |
700 | 1 | |a Xu, Ningze |e verfasserin |4 aut | |
700 | 1 | |a Pong, Raymond W |e verfasserin |4 aut | |
700 | 1 | |a Chen, Yingyao |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t International journal of technology assessment in health care |d 1985 |g 35(2019), 3 vom: 25. Jan., Seite 237-242 |w (DE-627)NLM013402048 |x 1471-6348 |7 nnns |
773 | 1 | 8 | |g volume:35 |g year:2019 |g number:3 |g day:25 |g month:01 |g pages:237-242 |
856 | 4 | 0 | |u http://dx.doi.org/10.1017/S0266462319000308 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 35 |j 2019 |e 3 |b 25 |c 01 |h 237-242 |