Synapsins regulate α-synuclein functions
Copyright © 2019 the Author(s). Published by PNAS..
The normal function of α-synuclein (α-syn) remains elusive. Although recent studies suggest α-syn as a physiologic attenuator of synaptic vesicle (SV) recycling, mechanisms are unclear. Here, we show that synapsin-a cytosolic protein with known roles in SV mobilization and clustering-is required for presynaptic functions of α-syn. Our data offer a critical missing link and advocate a model where α-syn and synapsin cooperate to cluster SVs and attenuate recycling.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2019 |
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Erschienen: |
2019 |
Enthalten in: |
Zur Gesamtaufnahme - volume:116 |
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Enthalten in: |
Proceedings of the National Academy of Sciences of the United States of America - 116(2019), 23 vom: 04. Juni, Seite 11116-11118 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Atias, Merav [VerfasserIn] |
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Links: |
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Themen: |
Alpha synuclein |
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Anmerkungen: |
Date Completed 25.03.2020 Date Revised 26.04.2020 published: Print-Electronic Citation Status MEDLINE |
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doi: |
10.1073/pnas.1903054116 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM297284592 |
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520 | |a The normal function of α-synuclein (α-syn) remains elusive. Although recent studies suggest α-syn as a physiologic attenuator of synaptic vesicle (SV) recycling, mechanisms are unclear. Here, we show that synapsin-a cytosolic protein with known roles in SV mobilization and clustering-is required for presynaptic functions of α-syn. Our data offer a critical missing link and advocate a model where α-syn and synapsin cooperate to cluster SVs and attenuate recycling | ||
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