Synapsins regulate α-synuclein functions

Copyright © 2019 the Author(s). Published by PNAS..

The normal function of α-synuclein (α-syn) remains elusive. Although recent studies suggest α-syn as a physiologic attenuator of synaptic vesicle (SV) recycling, mechanisms are unclear. Here, we show that synapsin-a cytosolic protein with known roles in SV mobilization and clustering-is required for presynaptic functions of α-syn. Our data offer a critical missing link and advocate a model where α-syn and synapsin cooperate to cluster SVs and attenuate recycling.

Medienart:

E-Artikel

Erscheinungsjahr:

2019

Erschienen:

2019

Enthalten in:

Zur Gesamtaufnahme - volume:116

Enthalten in:

Proceedings of the National Academy of Sciences of the United States of America - 116(2019), 23 vom: 04. Juni, Seite 11116-11118

Sprache:

Englisch

Beteiligte Personen:

Atias, Merav [VerfasserIn]
Tevet, Yaara [VerfasserIn]
Sun, Jichao [VerfasserIn]
Stavsky, Alexandra [VerfasserIn]
Tal, Shani [VerfasserIn]
Kahn, Joy [VerfasserIn]
Roy, Subhojit [VerfasserIn]
Gitler, Daniel [VerfasserIn]

Links:

Volltext

Themen:

Alpha synuclein
Alpha-Synuclein
Journal Article
Neurotransmission
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Synapsin
Synapsins

Anmerkungen:

Date Completed 25.03.2020

Date Revised 26.04.2020

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1073/pnas.1903054116

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM297284592