Predicting invasiveness and disease-specific survival in upper tract urothelial carcinoma : identifying relevant clinical tumour characteristics

PURPOSE: The aim of this prospective study was to identify the tumour characteristics that are associated with invasiveness and those that are relevant for disease-specific survival (DSS) in upper tract urothelial carcinoma, UTUC.

METHODS: From a prospective consecutive cohort of patients with suspicion of UTUC, those who were diagnosed with UTUC using URS prior to rNU between 2005 and 2012 were included. Tumour characteristics were analysed for prediction of invasiveness and association with DSS. Stages were categorised as superficial (pTa-1 and CIS only) or invasive (≥  pT2). Tumours were graded according to WHO 1999 classification. DSS was analysed regarding possible association with stage, grade, size, multifocality, location, ploidy and rate of proliferation. Associations were tested using Fisher's exact test, Pearson Chi-square or Cox's regression. Kaplan-Meier survival curves were constructed.

RESULTS: Forty-five consecutive patients were included, and 43 of them were included in the final analyses because their rNU specimens were available for reassessment. The only tumour characteristics that were significantly associated with stage were tumour grade (P < 0.001), DNA ploidy (P = 0.045) and rate of proliferation (P = 0.004). No association with stage was noted for size, multifocality or location. Grade, stage and rate of proliferation were associated with DSS.

CONCLUSIONS: Grade, DNA ploidy and S-phase fraction were the only tumour characteristics associated with stage in our study. However, DNA ploidy was not associated with DSS. The prognostic factors that we identified were tumour grade, stage, and S-phase fraction.

Medienart:

E-Artikel

Erscheinungsjahr:

2019

Erschienen:

2019

Enthalten in:

Zur Gesamtaufnahme - volume:37

Enthalten in:

World journal of urology - 37(2019), 11 vom: 23. Nov., Seite 2335-2342

Sprache:

Englisch

Beteiligte Personen:

Malm, Camilla [VerfasserIn]
Grahn, Alexandra [VerfasserIn]
Jaremko, Georg [VerfasserIn]
Tribukait, Bernhard [VerfasserIn]
Brehmer, Marianne [VerfasserIn]

Links:

Volltext

Themen:

Diagnostics
Disease-specific survival
Journal Article
Radical nephroureterectomy
Staging
Survival
Upper tract urothelial carcinoma
Ureteroscopy

Anmerkungen:

Date Completed 17.03.2020

Date Revised 09.01.2021

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1007/s00345-019-02760-4

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM296366463