Assessment of glucose variability in subjects with prediabetes
Copyright © 2019 Elsevier B.V. All rights reserved..
The aim of the study was to assess glucose variability in subjects with prediabetes by means of CGM.
MATERIAL AND METHODS: 32 subjects with prediabetes - mean age 56.6 ± 9.6 years, mean BMI 30.3 ± 5.3 kg/m2 and 18 subjects with normal glucose tolerance (NGT) - mean age 54.4 ± 9.9 years, mean BMI 24.8 ± 6.9 kg/m2, were enrolled. Glucose tolerance was studied during OGTT. HbA1c was measured by NGSP certified method. CGM was performed with FreeStyle Libre Pro sensor.
RESULTS: The following indices of glucose variability were significantly higher in the prediabetes group - CV (p < 0.041), J-index (p < 0.014), CONGA (p < 0.047) and GRADE (p < 0.036). A significant increase in HbA1c (p < 0.036), mean interstitial glucose (p < 0.025), time above range (p < 0.018) and a significant decrease in time in range (p < 0.014) was found in prediabetes compared to NGT. Significant correlations between HbA1c and LBGI (r = -0.33, p = 0.02), HBGI (r = 0.31, p = 0.03), CONGA (r = 0.36, p = 0.01), J-index (r = 0.37, p = 0.01) and M-value (r = -0.34, p = 0.02) were established.
CONCLUSION: Glucose variability is significantly increased in prediabetes and is an additional parameter in the assessment of glucose homeostasis even at these early stages of glucose dysregulation.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:151 |
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| Enthalten in: |
Diabetes research and clinical practice - 151(2019) vom: 30. Mai, Seite 56-64 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Chakarova, Nevena [VerfasserIn] |
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| Links: |
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| Themen: |
Blood Glucose |
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| Anmerkungen: |
Date Completed 12.08.2019 Date Revised 12.08.2019 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.diabres.2019.03.038 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 500 | |a Date Revised 12.08.2019 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2019 Elsevier B.V. All rights reserved. | ||
| 520 | |a The aim of the study was to assess glucose variability in subjects with prediabetes by means of CGM | ||
| 520 | |a MATERIAL AND METHODS: 32 subjects with prediabetes - mean age 56.6 ± 9.6 years, mean BMI 30.3 ± 5.3 kg/m2 and 18 subjects with normal glucose tolerance (NGT) - mean age 54.4 ± 9.9 years, mean BMI 24.8 ± 6.9 kg/m2, were enrolled. Glucose tolerance was studied during OGTT. HbA1c was measured by NGSP certified method. CGM was performed with FreeStyle Libre Pro sensor | ||
| 520 | |a RESULTS: The following indices of glucose variability were significantly higher in the prediabetes group - CV (p < 0.041), J-index (p < 0.014), CONGA (p < 0.047) and GRADE (p < 0.036). A significant increase in HbA1c (p < 0.036), mean interstitial glucose (p < 0.025), time above range (p < 0.018) and a significant decrease in time in range (p < 0.014) was found in prediabetes compared to NGT. Significant correlations between HbA1c and LBGI (r = -0.33, p = 0.02), HBGI (r = 0.31, p = 0.03), CONGA (r = 0.36, p = 0.01), J-index (r = 0.37, p = 0.01) and M-value (r = -0.34, p = 0.02) were established | ||
| 520 | |a CONCLUSION: Glucose variability is significantly increased in prediabetes and is an additional parameter in the assessment of glucose homeostasis even at these early stages of glucose dysregulation | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Continuous glucose monitoring | |
| 650 | 4 | |a Glucose variability | |
| 650 | 4 | |a Prediabetes | |
| 650 | 7 | |a Blood Glucose |2 NLM | |
| 700 | 1 | |a Dimova, Rumyana |e verfasserin |4 aut | |
| 700 | 1 | |a Grozeva, Greta |e verfasserin |4 aut | |
| 700 | 1 | |a Tankova, Tsvetalina |e verfasserin |4 aut | |
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