Multi-site repeatability and reproducibility of MR fingerprinting of the healthy brain at 1.5 and 3.0 T

Copyright © 2019 Elsevier Inc. All rights reserved..

Fully-quantitative MR imaging methods are useful for longitudinal characterization of disease and assessment of treatment efficacy. However, current quantitative MRI protocols have not been widely adopted in the clinic, mostly due to lengthy scan times. Magnetic Resonance Fingerprinting (MRF) is a new technique that can reconstruct multiple parametric maps from a single fast acquisition in the transient state of the MR signal. Due to the relative novelty of this technique, the repeatability and reproducibility of quantitative measurements obtained using MRF has not been extensively studied. Our study acquired test/retest data from the brains of nine healthy volunteers, each scanned on five MRI systems (two at 3.0 T and three at 1.5 T, all from a single vendor) located at two different centers. The pulse sequence and reconstruction algorithm were the same for all acquisitions. After registration of the MRF-derived M0, T1 and T2 maps to an anatomical atlas, coefficients-of-variation (CVs) were computed to assess test/retest repeatability and inter-site reproducibility in each voxel, while a General Linear Model (GLM) was used to determine the voxel-wise variability between all confounders, which included test/retest, subject, field strength and site. Our analysis demonstrated an excellent repeatability (CVs of 2-3% for T1, 5-8% for T2, 3% for normalized-M0) and a good reproducibility (CVs of 3-8% for T1, 8-14% for T2, 5% for normalized-M0) in grey and white matter.

Medienart:

E-Artikel

Erscheinungsjahr:

2019

Erschienen:

2019

Enthalten in:

Zur Gesamtaufnahme - volume:195

Enthalten in:

NeuroImage - 195(2019) vom: 15. Juli, Seite 362-372

Sprache:

Englisch

Beteiligte Personen:

Buonincontri, Guido [VerfasserIn]
Biagi, Laura [VerfasserIn]
Retico, Alessandra [VerfasserIn]
Cecchi, Paolo [VerfasserIn]
Cosottini, Mirco [VerfasserIn]
Gallagher, Ferdia A [VerfasserIn]
Gómez, Pedro A [VerfasserIn]
Graves, Martin J [VerfasserIn]
McLean, Mary A [VerfasserIn]
Riemer, Frank [VerfasserIn]
Schulte, Rolf F [VerfasserIn]
Tosetti, Michela [VerfasserIn]
Zaccagna, Fulvio [VerfasserIn]
Kaggie, Joshua D [VerfasserIn]

Links:

Volltext

Themen:

Brain
Journal Article
MR fingerprinting
MRI
Multicenter Study
Quantitation
Relaxometry
Research Support, Non-U.S. Gov't

Anmerkungen:

Date Completed 20.12.2019

Date Revised 10.02.2024

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1016/j.neuroimage.2019.03.047

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM295451637