Tonsillar and Adenoid Noncaseating, Epithelioid Granulomas in a Young Girl

Waldeyer's lymphatic ring granulomas in children are infrequent, and may represent an underlying systemic disease, often nondiagnosed before adenotonsillectomy is performed. The authors report on a 5-year-old otherwise healthy girl presented with remarkable tonsillar asymmetry as well as adenoid hypertrophy, with no systemic signs or complaints. Adenotonsillectomy was performed to rule out malignancy. Blood workup was normal. Microscopy of both adenoidectomy and tonsillectomy specimens showed multiple foci of epithelioid, noncaseating granulomas with giant multinucleated cells surrounded by nonspecific chronic inflammation. Immunostainings for B-cell markers, Ki-67, and Ziehl-Neelson were negative. This unusual pathology raised a differential diagnosis which included inflammatory diseases (sarcoidosis, Crohn's disease), foreign body reaction, lymphoma and infections (tuberculosis, fungi). However, none of these entities could be attributed to the girl's condition, and the reason for her pathologic findings remained unknown.

Medienart:

E-Artikel

Erscheinungsjahr:

2019

Erschienen:

2019

Enthalten in:

Zur Gesamtaufnahme - volume:30

Enthalten in:

The Journal of craniofacial surgery - 30(2019), 6 vom: 01. Sept., Seite e508-e511

Sprache:

Englisch

Beteiligte Personen:

Battat, Nir [VerfasserIn]
Tamir, Sharon Ovnat [VerfasserIn]
Marom, Tal [VerfasserIn]

Links:

Volltext

Themen:

Case Reports
Journal Article

Anmerkungen:

Date Completed 10.02.2020

Date Revised 10.02.2020

published: Print

Citation Status MEDLINE

doi:

10.1097/SCS.0000000000005415

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM29543239X