Age-Specific Features of Hypoxia Tolerance and Intensity of Lipopolysaccharide-Induced Systemic Inflammatory Response in Wistar Rats
Hypoxia tolerance and the intensity of systemic inflammatory response during endotoxemia were examined in newborn, prepubertal, and mature Wistar rats. To assess the sensitivity to hypoxia, the rats were placed into a pressure chamber simulating an altitude of 11,500 m. The systemic inflammatory response was provoked by intraperitoneal injection of LPS from E. coli O26:B6. Serum concentrations of HIF-1α, neopterin, C-reactive protein, and endotoxin were measured. In histological sections of the liver, the area of necrosis was assessed. The smallest tolerance of the prepubertal males to hypoxia correlated with the greatest manifestations of hepatic inflammation and elevated endotoxin, neopterin, and C-reactive protein. Elevation of serum HIF-1α in 3 h after LPC injection was observed in only prepubertal rats. The data obtained should be taken into account during the development of therapeutic strategy for prepubertal children with infectious and inflammatory diseases.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:166 |
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| Enthalten in: |
Bulletin of experimental biology and medicine - 166(2019), 5 vom: 22. März, Seite 699-703 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kosyreva, A M [VerfasserIn] |
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| Links: |
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| Themen: |
9007-41-4 |
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| Anmerkungen: |
Date Completed 22.07.2019 Date Revised 22.07.2019 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s10517-019-04421-3 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM295260246 |
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| 520 | |a Hypoxia tolerance and the intensity of systemic inflammatory response during endotoxemia were examined in newborn, prepubertal, and mature Wistar rats. To assess the sensitivity to hypoxia, the rats were placed into a pressure chamber simulating an altitude of 11,500 m. The systemic inflammatory response was provoked by intraperitoneal injection of LPS from E. coli O26:B6. Serum concentrations of HIF-1α, neopterin, C-reactive protein, and endotoxin were measured. In histological sections of the liver, the area of necrosis was assessed. The smallest tolerance of the prepubertal males to hypoxia correlated with the greatest manifestations of hepatic inflammation and elevated endotoxin, neopterin, and C-reactive protein. Elevation of serum HIF-1α in 3 h after LPC injection was observed in only prepubertal rats. The data obtained should be taken into account during the development of therapeutic strategy for prepubertal children with infectious and inflammatory diseases | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Makarova, O V |e verfasserin |4 aut | |
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