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From the magic bullet to the magic target : exploiting the diverse roles of DDX3X in viral infections and tumorigenesis

DDX3X is an ATPase/RNA helicase of the DEAD-box family and one of the most multifaceted helicases known up to date, acting in RNA metabolism, cell cycle control, apoptosis, stress response and innate immunity. Depending on the virus or the viral cycle stage, DDX3X can act either in a proviral fashion or as an antiviral factor. Similarly, in different cancer types, it can act either as an oncogene or a tumor-suppressor gene. Accumulating evidence indicated that DDX3X can be considered a promising target for anticancer and antiviral chemotherapy, but also that its exploitation requires a deeper understanding of the molecular mechanisms underlying its dual role in cancer and viral infections. In this Review, we will summarize the known roles of DDX3X in different tumor types and viral infections, and the different inhibitors available, illustrating the possible advantages and potential caveats of their use as anticancer and antiviral drugs

Year of Publication: 2019
Contained in: Future medicinal chemistry Vol. 11, No. 11 (2019), p. 1357-1381
All journal articles: Search for all articles in this journal
Language: English
Contributors: Riva, Valentina | Author
Maga, Giovanni
Full text access:
Electronic availability is being checked...
Links: Full Text (dx.doi.org)
Keywords: DEAD-box proteins
DNA viruses
Journal Article
RNA helicases
RNA viruses
anticancer chemotherapy
antiviral therapy
cancer
oncogene
tumor suppressor gene
ISSN: 1756-8927
Note: Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Notes: Date Revised 26.07.2019
published: Print-Electronic
Citation Status In-Data-Review
Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Physical Description: Online-Ressource
ID (e.g. DOI, URN): 10.4155/fmc-2018-0451
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