Biomimetic Metal-Organic Framework Nanoparticles for Cooperative Combination of Antiangiogenesis and Photodynamic Therapy for Enhanced Efficacy

© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim..

Photodynamic therapy (PDT) is a promising anticancer treatment and is clinically approved for different types of tumors. However, current PDT suffers several obstacles, including its neutralization by excess glutathione (GSH) in the tumor tissue and its strongly proangiogenic tumor response. In this work, a biomimic, multifunctional nanoparticle-based PDT agent, combining a tumor-targeted photosensitizer with GSH scavenging and antiangiogenesis therapy, is developed. A porphyrinic Zr-metal-organic framework nanoparticle is used simultaneously as the photosensitizer and the delivery vehicle of vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor apatinib. The core nanoparticles are wrapped in MnO2 to consume the intratumoral GSH and then decorated with a tumor cell membrane camouflage. After intravenous administration, the nanoparticles selectively accumulate in tumor through homotypic targeting mediated by the biomimic decoration, and the combination of enhanced PDT and antiangiogenic drug significantly improves their tumor inhibition efficiency. This study provides an integrated solution for mechanism-based enhancement of PDT and demonstrates the encouraging potential for multifunctional nanosystem applicable for tumor therapy.

Medienart:

E-Artikel

Erscheinungsjahr:

2019

Erschienen:

2019

Enthalten in:

Zur Gesamtaufnahme - volume:31

Enthalten in:

Advanced materials (Deerfield Beach, Fla.) - 31(2019), 15 vom: 12. Apr., Seite e1808200

Sprache:

Englisch

Beteiligte Personen:

Min, Huan [VerfasserIn]
Wang, Jing [VerfasserIn]
Qi, Yingqiu [VerfasserIn]
Zhang, Yinlong [VerfasserIn]
Han, Xuexiang [VerfasserIn]
Xu, Ying [VerfasserIn]
Xu, Junchao [VerfasserIn]
Li, Yao [VerfasserIn]
Chen, Long [VerfasserIn]
Cheng, Keman [VerfasserIn]
Liu, Guangna [VerfasserIn]
Yang, Na [VerfasserIn]
Li, Yiye [VerfasserIn]
Nie, Guangjun [VerfasserIn]

Links:

Volltext

Themen:

Angiogenesis Inhibitors
Angiogenesis inhibition
Antineoplastic Agents
Biomimetic nanoparticle
Glutathione metabolism
Journal Article
MOF
Metal-Organic Frameworks
Photodynamic therapy
Photosensitizing Agents

Anmerkungen:

Date Completed 31.07.2019

Date Revised 30.09.2020

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1002/adma.201808200

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM293991103