Synthesis of new boswellic acid derivatives as potential antiproliferative agents

In the current investigation, a series of heterocyclic derivatives of boswellic acids were prepared along with new monomers of 3-O-acetyl-11-keto-β-boswellic acid (AKBA, 1) 11-keto-β-boswellic acid (KBA, 2) and several new bis-AKBA and KBA homodimers and AKBA-KBA heterodimers. The effects of these compounds on the proliferation of different human cancer cell lines, viz., FaDu (pharynx carcinoma), A2780 (ovarian carcinoma), HT29 (colon adenocarcinoma), and A375 (malignant melanoma), have been evaluated. Thus, KBA homodimer 21 effectively inhibited the growth of FaDu, A2780, HT29, and A375 cells with EC50 values below 9 μM. In addition, compounds 7, 8, 11, 12, 15, 16, and 17 also exhibited cytotoxic effects for A2780, HT29, and A375 cancer cells. In particular, the pyrazine analog 8 was highly cytotoxic for A375 cancer cells with an EC50 value of 2.1 μM.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:34

Enthalten in:

Natural product research - 34(2020), 13 vom: 28. Juli, Seite 1845-1852

Sprache:

Englisch

Beteiligte Personen:

Shamraiz, Umair [VerfasserIn]
Hussain, Hidayat [VerfasserIn]
Ur Rehman, Najeeb [VerfasserIn]
Al-Shidhani, Sulaiman [VerfasserIn]
Saeed, Aasim [VerfasserIn]
Khan, Husain Yar [VerfasserIn]
Khan, Ajmal [VerfasserIn]
Fischer, Lucie [VerfasserIn]
Csuk, René [VerfasserIn]
Badshah, Amin [VerfasserIn]
Al-Rawahi, Ahmed [VerfasserIn]
Hussain, Javid [VerfasserIn]
Al-Harrasi, Ahmed [VerfasserIn]

Links:

Volltext

Themen:

11-keto-boswellic acid
631-69-6
AKBA-KBA heterodimers
Acetyl-11-ketoboswellic acid
Antineoplastic Agents
Boswellic acid
Cytotoxicity
Journal Article
Triterpenes

Anmerkungen:

Date Completed 21.08.2020

Date Revised 21.08.2020

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1080/14786419.2018.1564295

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM293185611