Cross-sectional comparison of health-span phenotypes in young versus geriatric marmosets

© 2019 Wiley Periodicals, Inc..

The development of the marmoset as a translational model for healthspan and lifespan studies relies on the characterization of health parameters in young and geriatric marmosets. This cross-sectional study examined health phenotypes in marmosets for five domains of interest for human health and aging: mobility, cognition, metabolism, homeostasis, and immune function. Geriatric marmosets were found to have significant executive function impairment when compared to young animals. While geriatric animals did not show gross abnormalities in mobility and measures of locomotion, their types of movement were altered from young animals. Geriatric marmosets had alterations in cardiac function, with significantly increased mean arterial pressures; metabolism, with significantly lower VO2 ; and suppressed immune function. Further, this study sought to characterize and describe histopathology for both young and geriatric healthy marmosets. Overall this study provides a characterization of health parameters for young and geriatric marmosets which will greatly enhance future aging and interventional testing in marmosets.

Medienart:

E-Artikel

Erscheinungsjahr:

2019

Erschienen:

2019

Enthalten in:

Zur Gesamtaufnahme - volume:81

Enthalten in:

American journal of primatology - 81(2019), 2 vom: 18. Feb., Seite e22952

Sprache:

Englisch

Beteiligte Personen:

Ross, Corinna N [VerfasserIn]
Adams, Jessica [VerfasserIn]
Gonzalez, Olga [VerfasserIn]
Dick, Edward [VerfasserIn]
Giavedoni, Luis [VerfasserIn]
Hodara, Vida L [VerfasserIn]
Phillips, Kimberley [VerfasserIn]
Rigodanzo, Anna D [VerfasserIn]
Kasinath, Balakuntalam [VerfasserIn]
Tardif, Suzette D [VerfasserIn]

Links:

Volltext

Themen:

Animal models
Biomarkers of aging
Comparative Study
Healthspan
Journal Article
Longevity
Nonhuman primates
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Anmerkungen:

Date Completed 08.01.2020

Date Revised 25.02.2020

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1002/ajp.22952

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM292919662