Metal-free, intermolecular carbopyridylation of alkenes via visible-light-induced reductive radical coupling
An efficient, metal-free strategy for the intermolecular three-component carbopyridylation of styrenes, enabled by Hantzsch ester and visible light, has been described. This versatile protocol gives access to important β-CF3 pyridines, through the regioselective, sequential formation of two C-C bonds without the use of exogenous catalysts. The value of this benign protocol has been demonstrated through functionalizations of natural-product- and drug-based complex molecules.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2018 |
---|---|
Erschienen: |
2018 |
Enthalten in: |
Zur Gesamtaufnahme - volume:9 |
---|---|
Enthalten in: |
Chemical science - 9(2018), 48 vom: 28. Dez., Seite 9012-9017 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Chen, Dan [VerfasserIn] |
---|
Links: |
---|
Themen: |
---|
Anmerkungen: |
Date Revised 30.09.2020 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
---|
doi: |
10.1039/c8sc03493a |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM292758510 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM292758510 | ||
003 | DE-627 | ||
005 | 20231225073825.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231225s2018 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1039/c8sc03493a |2 doi | |
028 | 5 | 2 | |a pubmed24n0975.xml |
035 | |a (DE-627)NLM292758510 | ||
035 | |a (NLM)30647893 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Chen, Dan |e verfasserin |4 aut | |
245 | 1 | 0 | |a Metal-free, intermolecular carbopyridylation of alkenes via visible-light-induced reductive radical coupling |
264 | 1 | |c 2018 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Revised 30.09.2020 | ||
500 | |a published: Electronic-eCollection | ||
500 | |a Citation Status PubMed-not-MEDLINE | ||
520 | |a An efficient, metal-free strategy for the intermolecular three-component carbopyridylation of styrenes, enabled by Hantzsch ester and visible light, has been described. This versatile protocol gives access to important β-CF3 pyridines, through the regioselective, sequential formation of two C-C bonds without the use of exogenous catalysts. The value of this benign protocol has been demonstrated through functionalizations of natural-product- and drug-based complex molecules | ||
650 | 4 | |a Journal Article | |
700 | 1 | |a Xu, Lei |e verfasserin |4 aut | |
700 | 1 | |a Long, Tianyu |e verfasserin |4 aut | |
700 | 1 | |a Zhu, Shengqing |e verfasserin |4 aut | |
700 | 1 | |a Yang, Jun |e verfasserin |4 aut | |
700 | 1 | |a Chu, Lingling |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Chemical science |d 2010 |g 9(2018), 48 vom: 28. Dez., Seite 9012-9017 |w (DE-627)NLM204906237 |x 2041-6520 |7 nnns |
773 | 1 | 8 | |g volume:9 |g year:2018 |g number:48 |g day:28 |g month:12 |g pages:9012-9017 |
856 | 4 | 0 | |u http://dx.doi.org/10.1039/c8sc03493a |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 9 |j 2018 |e 48 |b 28 |c 12 |h 9012-9017 |