Blog
Feedback
schliessen

Filtern

 

Bibliotheken

Logo der Bibliothek

Logo FID Pharmazie PubPharm Discovery System Universitätsbibliothek Braunschweig Institut für Informationssysteme

Targeting Strategies for Glucose Metabolic Pathways and T Cells in Colorectal Cancer

Colorectal cancer is a heterogeneous group of diseases that result from the accumulation of different sets of genomic alterations, together with epigenomic alterations, and it is influenced by tumor-host interactions, leading to tumor cell growth and glycolytic imbalances. This review summarizes recent findings that involve multiple signaling molecules and downstream genes in the dysregulated glycolytic pathway. This paper further discusses the role of the dysregulated glycolytic pathway in the tumor initiation, progression and the concomitant systemic immunosuppression commonly observed in colorectal cancer patients. Moreover, the relationship between colorectal cancer cells and T cells, especially CD8+ T cells, is discussed, while different aspects of metabolic pathway regulation in cancer cell proliferation are comprehensively defined. Furthermore, this study elaborates on metabolism in colorectal cancer, specifically key metabolic modulators together with regulators, glycolytic enzymes, and glucose deprivation induced by tumor cells and how they inhibit T-cell glycolysis and immunogenic functions. Moreover, metabolic pathways that are integral to T cell function, differentiation, and activation are described. Selective metabolic inhibitors or immunemodulation agents targeting these pathways may be clinically useful to increase effector T cell responses for colorectal cancer treatment. However, there is a need to identify specific antigens using a cancer patient-personalized approach and combination strategies with other therapeutic agents to effectively target tumor metabolic pathways

Year of Publication: 2019
Contained in: Current cancer drug targets Vol. 19, No. 7 (2019), p. 534-550
All journal articles: Search for all articles in this journal
Language: English
Contributors: Wang, Gang | Author
Wang, Jun-Jie
Guan, Rui
Sun, Yan
Shi, Feng
Gao, Jing
Fu, Xing-Li
Full text access:
Electronic availability is being checked...
Links: Full Text (dx.doi.org)
Keywords: Colorectal cancers
Journal Article
T cells
genomic alterations
glucose metabolism
immune microenvironment
therapy.
ISSN: 1873-5576
Note: Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Notes: Date Revised 11.09.2019
published: Print
Citation Status In-Data-Review
Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Physical Description: Online-Ressource
ID (e.g. DOI, URN): 10.2174/1568009618666181015150138
more publication details ...

Associated Publications

  • Associated records are being queried...
more (+)
Internes Format
LEADER 03494nma a2200577 c 4500
001 NLM290373743
003 DE-601
005 20200220013855.0
007 cr uuu---uuuuu
008 181105s2019 000 0 eng d
024 7 |a 10.2174/1568009618666181015150138  |2 doi 
028 5 2 |a pubmed20n0966.xml 
035 |a (DE-599)NLM30360743 
040 |b ger  |c GBVCP 
041 0 |a eng 
100 1 |a Wang, Gang 
245 1 0 |a Targeting Strategies for Glucose Metabolic Pathways and T Cells in Colorectal Cancer  |h Elektronische Ressource 
300 |a Online-Ressource 
500 |a Date Revised 11.09.2019 
500 |a published: Print 
500 |a Citation Status In-Data-Review 
500 |a Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine 
520 |a Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net. 
520 |a Colorectal cancer is a heterogeneous group of diseases that result from the accumulation of different sets of genomic alterations, together with epigenomic alterations, and it is influenced by tumor-host interactions, leading to tumor cell growth and glycolytic imbalances. This review summarizes recent findings that involve multiple signaling molecules and downstream genes in the dysregulated glycolytic pathway. This paper further discusses the role of the dysregulated glycolytic pathway in the tumor initiation, progression and the concomitant systemic immunosuppression commonly observed in colorectal cancer patients. Moreover, the relationship between colorectal cancer cells and T cells, especially CD8+ T cells, is discussed, while different aspects of metabolic pathway regulation in cancer cell proliferation are comprehensively defined. Furthermore, this study elaborates on metabolism in colorectal cancer, specifically key metabolic modulators together with regulators, glycolytic enzymes, and glucose deprivation induced by tumor cells and how they inhibit T-cell glycolysis and immunogenic functions. Moreover, metabolic pathways that are integral to T cell function, differentiation, and activation are described. Selective metabolic inhibitors or immunemodulation agents targeting these pathways may be clinically useful to increase effector T cell responses for colorectal cancer treatment. However, there is a need to identify specific antigens using a cancer patient-personalized approach and combination strategies with other therapeutic agents to effectively target tumor metabolic pathways 
611 2 7 |a Journal Article  |2 gnd 
655 7 |a Colorectal cancers  |2 gnd 
655 7 |a T cells  |2 gnd 
655 7 |a genomic alterations  |2 gnd 
655 7 |a glucose metabolism  |2 gnd 
655 7 |a immune microenvironment  |2 gnd 
655 7 |a therapy.  |2 gnd 
689 0 0 |A f  |a Journal Article 
689 0 |5 DE-601 
689 1 0 |a Colorectal cancers 
689 1 1 |a T cells 
689 1 2 |a genomic alterations 
689 1 3 |a glucose metabolism 
689 1 4 |a immune microenvironment 
689 1 5 |a therapy. 
689 1 |5 DE-601 
700 1 |a Wang, Jun-Jie 
700 1 |a Guan, Rui 
700 1 |a Sun, Yan 
700 1 |a Shi, Feng 
700 1 |a Gao, Jing 
700 1 |a Fu, Xing-Li 
773 0 8 |i in  |t Current cancer drug targets  |g Vol. 19, No. 7 (2019), p. 534-550  |q 19:7<534-550  |w (DE-601)NLM120493810  |x 1873-5576 
856 4 1 |u http://dx.doi.org/10.2174/1568009618666181015150138  |3 Volltext 
912 |a GBV_NLM 
951 |a AR 
952 |d 19  |j 2019  |e 7  |h 534-550