Neuroprotective effects of berberine on recognition memory impairment, oxidative stress, and damage to the purinergic system in rats submitted to intracerebroventricular injection of streptozotocin

Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disease. The present study investigated the effects of 50 and 100 mg/kg berberine (BRB) on recognition memory, oxidative stress, and purinergic neurotransmission, in a model of sporadic dementia of the Alzheimer's type induced by intracerebroventricular (ICV) injection of streptozotocin (STZ) in rats. Rats were submitted to ICV-STZ 3 mg/kg or saline, and 3 days later, were started on a treatment of BRB or saline for 21 days. The results demonstrated that BRB was effective in protecting against memory impairment, increased reactive oxygen species, and the subsequent increase in protein and lipid oxidation in the cerebral cortex and hippocampus, as well as δ-aminolevulinate dehydratase inhibition in the cerebral cortex. Moreover, the decrease in total thiols, and the reduced glutathione and glutathione S-transferase activity in the cerebral cortex and hippocampus of ICV-STZ rats, was prevented by BRB treatment. Besides an antioxidant effect, BRB treatment was capable of preventing decreases in ecto-nucleoside triphosphate diphosphohydrolase (NTPDase), 5'-nucleotidase (EC-5'-Nt), and adenosine deaminase (ADA) activities in synaptosomes of the cerebral cortex and hippocampus. Thus, our data suggest that BRB exerts a neuroprotective effect on recognition memory, as well as on oxidative stress and oxidative stress-related damage, such as dysfunction of the purinergic system. This suggests that BRB may act as a promising multipotent agent for the treatment of AD.

Media Type:

Electronic Article

Year of Publication:

2019

Publication:

2019

Contained In:

To Main Record - volume:236

Contained In:

Psychopharmacology - 236(2019), 2 vom: 25. Feb., Seite 641-655

Language:

English

Contributors:

de Oliveira, Juliana Sorraila [Author]
Abdalla, Fátima Husein [Author]
Dornelles, Guilherme Lopes [Author]
Palma, Taís Vidal [Author]
Signor, Cristiane [Author]
da Silva Bernardi, Jamile [Author]
Baldissarelli, Jucimara [Author]
Lenz, Luana Suéling [Author]
de Oliveira, Vitor Antunes [Author]
Chitolina Schetinger, Maria Rosa [Author]
Melchiors Morsch, Vera Maria [Author]
Rubin, Maribel Antonello [Author]
de Andrade, Cinthia Melazzo [Author]

Links:

Volltext

Keywords:

0I8Y3P32UF
5'-Nucleotidase
5W494URQ81
Adenosine Deaminase
Alzheimer
Antibiotics, Antineoplastic
Antioxidant
Antioxidants
Berberine
EC 2.5.1.18
EC 3.1.3.5
EC 3.5.4.4
EC 3.6.1.-
Ectoenzymes
GAN16C9B8O
Glutathione
Glutathione Transferase
Journal Article
Neuroprotective Agents
Pyrophosphatases
Reactive Oxygen Species
Reactive species
Streptozocin

Notes:

Date Completed 07.05.2019

Date Revised 25.02.2020

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1007/s00213-018-5090-6

funding:

Supporting institution / Project title:

PPN (Catalogue-ID):

NLM290113687