Tumor Thickness and Modified Clark Level in Canine Cutaneous Melanocytic Tumors

Breslow thickness and Clark level are prognostic factors for human cutaneous melanomas. Breslow thickness is measured with an ocular micrometer from the top of the granular layer of the epidermis to the deepest invasive cell across the broad base of the tumor, while Clark level is based on the anatomical level of invasion through the layers of the dermis. Because of the anatomical differences between humans and dogs, we evaluated the tumor thickness and a modified Clark level in 77 canine primary cutaneous melanocytic tumors. Tumor thickness (using both a traditional and a more convenient system) and modified Clark level were measured and associated with histological diagnosis and clinical outcome. Tumor thickness was a prognostic factor, being greater in animals with shorter overall survival and disease-free time. Cutoffs of 0.95 cm and 0.75 cm defined a higher hazard for an unfavorable outcome and to develop recurrence/metastasis, respectively. Because of an excellent agreement between the 2 methods, it was concluded that tumor thickness could be measured with a ruler when an ocular micrometer is not available. Modified Clark level was not found to be relevant for prognosis. However, we suggest that both tumor thickness and a modified Clark level can be valid additional parameters when histological diagnosis is uncertain. Further studies, including a wider sample population, would be worthwhile to confirm the prognostic significance of these 2 parameters.

Medienart:

E-Artikel

Erscheinungsjahr:

2019

Erschienen:

2019

Enthalten in:

Zur Gesamtaufnahme - volume:56

Enthalten in:

Veterinary pathology - 56(2019), 2 vom: 01. März, Seite 180-188

Sprache:

Englisch

Beteiligte Personen:

Silvestri, Serenella [VerfasserIn]
Porcellato, Ilaria [VerfasserIn]
Mechelli, Luca [VerfasserIn]
Menchetti, Laura [VerfasserIn]
Rapastella, Sofia [VerfasserIn]
Brachelente, Chiara [VerfasserIn]

Links:

Volltext

Themen:

Dogs
Journal Article
Melanoma
Modified Clark level
Neoplasia
Prognosis
Skin
Survival
Tumor thickness

Anmerkungen:

Date Completed 07.05.2019

Date Revised 07.05.2019

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1177/0300985818798094

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM288810805