Role of Interleukin-38 in Chronic Inflammatory Diseases : A Comprehensive Review

Interleukin (IL)-38 is the newest member of the IL-1 family. It can bind to several receptors, regulate the generation, function of inflammatory cytokines through the downstream signaling pathways. IL-38 is expressed in several tissues, such as placenta, heart, and brain. It is involved in a wide variety of diseases, including chronic inflammatory diseases. In this review, we discuss the expression and biological functions of IL-38, especially the role in rheumatic autoimmune diseases. Collection of the information may improve the understanding of IL-38, and may give potential for theoretical basis for clinical trials and drug development in the future.

Medienart:

E-Artikel

Erscheinungsjahr:

2018

Erschienen:

2018

Enthalten in:

Zur Gesamtaufnahme - volume:9

Enthalten in:

Frontiers in immunology - 9(2018) vom: 01., Seite 1462

Sprache:

Englisch

Beteiligte Personen:

Xu, Wang-Dong [VerfasserIn]
Huang, An-Fang [VerfasserIn]

Links:

Volltext

Themen:

Autoimmunity
Immune cell
Inflammation
Interleukin-38
Journal Article
Review
Signaling pathway

Anmerkungen:

Date Revised 20.11.2019

published: Electronic-eCollection

Citation Status PubMed-not-MEDLINE

doi:

10.3389/fimmu.2018.01462

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM286310147