Role of Interleukin-38 in Chronic Inflammatory Diseases : A Comprehensive Review
Interleukin (IL)-38 is the newest member of the IL-1 family. It can bind to several receptors, regulate the generation, function of inflammatory cytokines through the downstream signaling pathways. IL-38 is expressed in several tissues, such as placenta, heart, and brain. It is involved in a wide variety of diseases, including chronic inflammatory diseases. In this review, we discuss the expression and biological functions of IL-38, especially the role in rheumatic autoimmune diseases. Collection of the information may improve the understanding of IL-38, and may give potential for theoretical basis for clinical trials and drug development in the future.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2018 |
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Erschienen: |
2018 |
Enthalten in: |
Zur Gesamtaufnahme - volume:9 |
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Enthalten in: |
Frontiers in immunology - 9(2018) vom: 01., Seite 1462 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Xu, Wang-Dong [VerfasserIn] |
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Links: |
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Themen: |
Autoimmunity |
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Anmerkungen: |
Date Revised 20.11.2019 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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doi: |
10.3389/fimmu.2018.01462 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM286310147 |
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