Anti-inflammatory effects of newly synthesized α-galacto-oligosaccharides on dextran sulfate sodium-induced colitis in C57BL/6J mice

Copyright © 2018 Elsevier Ltd. All rights reserved..

α-Galacto-oligosaccharides have been reported to have beneficial health effects. The purpose of this study was to investigate the preventive effects of a newly synthesized α-galacto-oligosaccharide mixture (α-GOSg), as well as raffinose family oligosaccharides (RFOs), on dextran sulfate sodium (DSS)-induced colitis in mice. When administered in drinking water at 0.5% for 15 days, both α-GOSg and RFOs significantly decreased fecal hemoglobin content, partially prevented colon length shortening, reduced the severity of colon inflammation, and attenuated DSS-induced upregulation of cyclooxygenase-2. In addition, the activation of the inflammatory regulator nuclear factor-kappa B was slightly inhibited by α-GOSg. The results showed that the newly synthesized α-GOSg preparation has similar anti-inflammatory activities as RFOs in this colitis model. The anti-inflammatory activity of α-GOSg in humans remains to be investigated.

Medienart:

E-Artikel

Erscheinungsjahr:

2018

Erschienen:

2018

Enthalten in:

Zur Gesamtaufnahme - volume:109

Enthalten in:

Food research international (Ottawa, Ont.) - 109(2018) vom: 04. Juli, Seite 350-357

Sprache:

Englisch

Beteiligte Personen:

Dai, Zhuqing [VerfasserIn]
Feng, Simin [VerfasserIn]
Liu, Anna [VerfasserIn]
Wang, Hong [VerfasserIn]
Zeng, Xiaoxiong [VerfasserIn]
Yang, Chung S [VerfasserIn]

Links:

Volltext

Themen:

α-GOSg
81627-83-0
9042-14-2
Anti-Inflammatory Agents
Anti-inflammatory
Colitis
Cyclooxygenase 2
Cyclooxygenase-2
Dextran Sulfate
EC 1.14.99.-
EC 1.14.99.1
Hemoglobins
Journal Article
Macrophage Colony-Stimulating Factor
Oligosaccharides
Ptgs2 protein, mouse
Rela protein, mouse
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Transcription Factor RelA

Anmerkungen:

Date Completed 07.11.2019

Date Revised 18.03.2024

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1016/j.foodres.2018.04.054

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM28449013X