Induced Pluripotent Stem Cell-Derived Hematopoietic Embryoid Bodies Secrete Sphingosine-1-Phosphate and Revert Endothelial Injury
The possibility of sphingosine-1-phosphate production by induced pluripotent stem cells is examined to assess their potential in treatment of sepsis. The hematopoietic embryoid bodies were derived from the culture of 6-day-old differentiated induced pluripotent stem cells. These embryoid bodies secreted sphingosine-1-phosphate, an important bioactive lipid that regulates integrity of the pulmonary endothelial barrier, prevents elevation of its permeability, and impedes the formation of stress fibers in human endotheliocytes derived from umbilical vein. The data attest to potentiality of induced pluripotent stem cells in treatment of sepsis.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2018 |
|---|---|
| Erschienen: |
2018 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:164 |
|---|---|
| Enthalten in: |
Bulletin of experimental biology and medicine - 164(2018), 6 vom: 15. Apr., Seite 775-779 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Kasuda, S [VerfasserIn] |
|---|
| Links: |
|---|
| Anmerkungen: |
Date Completed 19.09.2018 Date Revised 02.12.2018 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1007/s10517-018-4078-x |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM283064781 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM283064781 | ||
| 003 | DE-627 | ||
| 005 | 20231225035525.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2018 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s10517-018-4078-x |2 doi | |
| 028 | 5 | 2 | |a pubmed24n0943.xml |
| 035 | |a (DE-627)NLM283064781 | ||
| 035 | |a (NLM)29658075 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Kasuda, S |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Induced Pluripotent Stem Cell-Derived Hematopoietic Embryoid Bodies Secrete Sphingosine-1-Phosphate and Revert Endothelial Injury |
| 264 | 1 | |c 2018 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 19.09.2018 | ||
| 500 | |a Date Revised 02.12.2018 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a The possibility of sphingosine-1-phosphate production by induced pluripotent stem cells is examined to assess their potential in treatment of sepsis. The hematopoietic embryoid bodies were derived from the culture of 6-day-old differentiated induced pluripotent stem cells. These embryoid bodies secreted sphingosine-1-phosphate, an important bioactive lipid that regulates integrity of the pulmonary endothelial barrier, prevents elevation of its permeability, and impedes the formation of stress fibers in human endotheliocytes derived from umbilical vein. The data attest to potentiality of induced pluripotent stem cells in treatment of sepsis | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a endotheliocytes | |
| 650 | 4 | |a induced pluripotent stem cells | |
| 650 | 4 | |a sepsis | |
| 650 | 4 | |a sphingosine-1-phosphate | |
| 650 | 7 | |a GATA1 Transcription Factor |2 NLM | |
| 650 | 7 | |a Gata1 protein, mouse |2 NLM | |
| 650 | 7 | |a Lipopolysaccharides |2 NLM | |
| 650 | 7 | |a Lysophospholipids |2 NLM | |
| 650 | 7 | |a Rex-1 protein, mouse |2 NLM | |
| 650 | 7 | |a Transcription Factors |2 NLM | |
| 650 | 7 | |a sphingosine 1-phosphate |2 NLM | |
| 650 | 7 | |a 26993-30-6 |2 NLM | |
| 650 | 7 | |a Phosphotransferases (Alcohol Group Acceptor) |2 NLM | |
| 650 | 7 | |a EC 2.7.1.- |2 NLM | |
| 650 | 7 | |a sphingosine kinase |2 NLM | |
| 650 | 7 | |a EC 2.7.1.- |2 NLM | |
| 650 | 7 | |a sphingosine kinase 2, mouse |2 NLM | |
| 650 | 7 | |a EC 2.7.1.- |2 NLM | |
| 650 | 7 | |a Vascular Endothelial Growth Factor Receptor-2 |2 NLM | |
| 650 | 7 | |a EC 2.7.10.1 |2 NLM | |
| 650 | 7 | |a Sphingosine |2 NLM | |
| 650 | 7 | |a NGZ37HRE42 |2 NLM | |
| 700 | 1 | |a Kudo, R |e verfasserin |4 aut | |
| 700 | 1 | |a Yuui, K |e verfasserin |4 aut | |
| 700 | 1 | |a Sakurai, Y |e verfasserin |4 aut | |
| 700 | 1 | |a Hatake, K |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Bulletin of experimental biology and medicine |d 1974 |g 164(2018), 6 vom: 15. Apr., Seite 775-779 |w (DE-627)NLM000481815 |x 1573-8221 |7 nnns |
| 773 | 1 | 8 | |g volume:164 |g year:2018 |g number:6 |g day:15 |g month:04 |g pages:775-779 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1007/s10517-018-4078-x |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 164 |j 2018 |e 6 |b 15 |c 04 |h 775-779 | ||