New lignan from the rattan stems of Schisandra chinensis
A new lignan named schilignan F (1), together with twelve known ones (2-13), were isolated from the rattan stems of Schisandra chinensis. Their chemical structures were elucidated by spectroscopic methods including one and two-dimensional NMR spectra referring to the literatures as well as high-resolution mass spectrometric analysis. All compounds were evaluated for their cytotoxicities against human Hela cancer cell lines in vitro. The results showed that compounds 2, 6 and 8 exhibited weak cytotoxic activity with IC50 values of 30.6, 86.3 and 41.0 μM, and cisplatin showed cytotoxic activity with IC50 value of 27.3 μM.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:33 |
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| Enthalten in: |
Natural product research - 33(2019), 3 vom: 14. Feb., Seite 340-346 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Yang, Bing-You [VerfasserIn] |
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| Links: |
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| Themen: |
Antineoplastic Agents |
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| Anmerkungen: |
Date Completed 11.06.2019 Date Revised 13.06.2019 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1080/14786419.2018.1452000 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM282003827 |
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| 520 | |a A new lignan named schilignan F (1), together with twelve known ones (2-13), were isolated from the rattan stems of Schisandra chinensis. Their chemical structures were elucidated by spectroscopic methods including one and two-dimensional NMR spectra referring to the literatures as well as high-resolution mass spectrometric analysis. All compounds were evaluated for their cytotoxicities against human Hela cancer cell lines in vitro. The results showed that compounds 2, 6 and 8 exhibited weak cytotoxic activity with IC50 values of 30.6, 86.3 and 41.0 μM, and cisplatin showed cytotoxic activity with IC50 value of 27.3 μM | ||
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| 700 | 1 | |a Kuang, Hai-Xue |e verfasserin |4 aut | |
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