Endothelin-1 and Its Receptors ETA and ETB in Drug-Induced Gingival Overgrowth
© 2007 American Academy of Periodontology..
BACKGROUND: The purpose of this study was to study the expression of endothelin-1 (ET-1) and its receptors ETA and ETB in normal human gingiva and cyclosporin-induced gingival fibroblasts.
METHODS: Gingival samples were collected from eight normal healthy individuals, eight patients with periodontitis, and eight patients with cyclosporin A (CsA)-induced gingival overgrowth. Total RNA was extracted from tissue samples, and reverse transcriptase-polymerase chain reaction was performed for ET-1, ETA , and ETB . ET-1 protein was estimated from the tissues by enzyme-linked immunosorbent assay. The expression of ET-1 and its receptors was also examined in gingival fibroblast cells treated with CsA.
RESULTS: ET-1 mRNA expression was significantly higher in patients with CsA-induced gingival overgrowth (P <0.001) than in patients with periodontitis and the controls. ETA mRNA was expressed more than the ETB in all examined samples. In human gingival fibroblasts, ET-1 expression was increased with CsA incorporation compared to controls (P <0.001).
CONCLUSION: These results suggest that CsA can modulate the expression of ET-1 in gingival fibroblasts and CsA-induced gingival overgrowth.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2007 |
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| Erschienen: |
2007 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:78 |
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| Enthalten in: |
Journal of periodontology - 78(2007), 2 vom: 01. Feb., Seite 290-295 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Tamilselvan, S [VerfasserIn] |
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| Links: |
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| Themen: |
Cyclosporin |
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| Anmerkungen: |
Date Revised 20.11.2019 published: Print Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1902/jop.2007.060172 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM281953325 |
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| 245 | 1 | 0 | |a Endothelin-1 and Its Receptors ETA and ETB in Drug-Induced Gingival Overgrowth |
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| 500 | |a Date Revised 20.11.2019 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a © 2007 American Academy of Periodontology. | ||
| 520 | |a BACKGROUND: The purpose of this study was to study the expression of endothelin-1 (ET-1) and its receptors ETA and ETB in normal human gingiva and cyclosporin-induced gingival fibroblasts | ||
| 520 | |a METHODS: Gingival samples were collected from eight normal healthy individuals, eight patients with periodontitis, and eight patients with cyclosporin A (CsA)-induced gingival overgrowth. Total RNA was extracted from tissue samples, and reverse transcriptase-polymerase chain reaction was performed for ET-1, ETA , and ETB . ET-1 protein was estimated from the tissues by enzyme-linked immunosorbent assay. The expression of ET-1 and its receptors was also examined in gingival fibroblast cells treated with CsA | ||
| 520 | |a RESULTS: ET-1 mRNA expression was significantly higher in patients with CsA-induced gingival overgrowth (P <0.001) than in patients with periodontitis and the controls. ETA mRNA was expressed more than the ETB in all examined samples. In human gingival fibroblasts, ET-1 expression was increased with CsA incorporation compared to controls (P <0.001) | ||
| 520 | |a CONCLUSION: These results suggest that CsA can modulate the expression of ET-1 in gingival fibroblasts and CsA-induced gingival overgrowth | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Cyclosporin | |
| 650 | 4 | |a endothelin receptors | |
| 650 | 4 | |a endothelin-1 | |
| 650 | 4 | |a fibroblast | |
| 650 | 4 | |a gingival overgrowth | |
| 650 | 4 | |a periodontitis | |
| 700 | 1 | |a Raju, Surya Narayana |e verfasserin |4 aut | |
| 700 | 1 | |a Loganathan, D |e verfasserin |4 aut | |
| 700 | 1 | |a Kamatchiammal, S |e verfasserin |4 aut | |
| 700 | 1 | |a Abraham, Georgie |e verfasserin |4 aut | |
| 700 | 1 | |a Suresh, R |e verfasserin |4 aut | |
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