Retrospective analysis of HDFN due to ABO incompatibility in a single institution over 6 years

© 2018 British Blood Transfusion Society..

OBJECTIVES: To study the rate of ABO haemolytic anaemia of fetus and newborn (HDFN) in one institution over 6 years.

BACKGROUND: ABO major incompatibility between mothers and their newborns occurs in about 10% of births. So, mothers with an O blood group may form IgG-class antibodies against A and B antigens, which could pass across the placenta and lead to a variable degree of HDFN in the newborn.

METHODS: At our institution, we have reviewed data regarding ABO-based HDFN in the last 6 years.

RESULTS: We found that, in 28 089 deliveries, an ABO major incompatibility between mothers and newborns occurs in 11% of cases, with 72% of O/A and 28% of O/B incompatibility. In turn, 23% of these newborns had an eluate-confirmed positive direct antiglobulin test [DAT; 74% (511) were due to anti-A and 26% (179) to anti-B], with 1·0% requiring invasive treatments (exchange transfusion or intravenous immunoglobulin). Overall, 2·5% of the total newborns had a positive DAT for an anti-A or anti-B antibody, and 0·11% required invasive treatment in addition to phototherapy for their HDFN.

CONCLUSIONS: Serological ABO HDFN is a relatively frequent event when an O-A/O-B incompatibility between mothers and their newborn occurs and, in most cases, translates into a self-limiting disease, with a small number of newborns requiring invasive treatments. The DAT test, although not predictive of disease severity, appears to be a useful tool to monitor babies born from O-A/O-B-incompatible pregnancies and to identify those who may require treatment.

Medienart:

E-Artikel

Erscheinungsjahr:

2019

Erschienen:

2019

Enthalten in:

Zur Gesamtaufnahme - volume:29

Enthalten in:

Transfusion medicine (Oxford, England) - 29(2019), 3 vom: 26. Juni, Seite 197-201

Sprache:

Englisch

Beteiligte Personen:

Matteocci, A [VerfasserIn]
De Rosa, A [VerfasserIn]
Buffone, E [VerfasserIn]
Pierelli, L [VerfasserIn]

Links:

Volltext

Themen:

ABO Blood-Group System
ABO incompatibility
ABO red cell antigens
DAT
Haemolytic disease of fetus and newborn
Immune anti-A/anti-B IgG antibodies
Isoantibodies
Journal Article

Anmerkungen:

Date Completed 25.12.2019

Date Revised 25.12.2019

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1111/tme.12512

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM280299796